Fig. 5
From: CYFRA21-1 is a more sensitive biomarker to assess the severity of pulmonary alveolar proteinosis
Receiver operating characteristic curve (ROC) of correlating serum biomarkers. A LDH value and PAP (critical point: 146 U/L, AUC: 0.848, 95% CI [0.791–0.906], sensitivity: 0.921, specificity: 0.684); CEA value and PAP (critical point: 1.47 ug/L, AUC: 0.815, 95% CI [0.757–0.874], sensitivity: 0.762, specificity: 0.789); CYFRA21-1 value and PAP (critical point: 2.01 ng/ml, AUC: 0.852, 95% CI [0.797–0.906], sensitivity: 0.874, specificity: 0.684). B: LDH value and PAP severity (critical point: 203 U/L, AUC: 0.780, 95% CI [0.707–0.853], sensitivity: 0.713, specificity: 0.719); CEA value and PAP severity (critical point: 2.56 ug/L, AUC: 0.750, 95% CI [0.671–0.829], sensitivity: 0.755, specificity: 0.659); CYFRA21-1 value and PAP severity (critical point: 5.57 ng/ml, AUC: 0.815, 95% CI [0.748–0.882], sensitivity: 0.606, specificity: 0.877)