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Table 3 Correlation between cytokines, vitamin D level, scores of symptoms, lung function, quality of life and other inflammatory markers (Spearman’s coefficient)

From: Systemic and local cytokine profile and risk factors for persistent allergic airway inflammation in patients sensitised to house dust mite allergens

 

IL-22

IL-17

IL-33

IL-10

IL-13

IFN-gamma

 

Serum

Nasal lavage

Serum

Nasal lavage

Serum

Nasal lavage

Serum

Nasal lavage

Serum

Nasal lavage

Serum

Nasal lavage

Patients with AR

TNSS

− 0.19

− 0.04

− 0.19

0.03

− 0.06

− 0.05

− 0.23

− 0.15

− 0.17

0.16

− 0.05

− 0.35*

ACT

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

RQLQ

− 0.11

0.04

− 0.12

0.10

− 0.02

0.08

− 0.04

− 0.22

− 0.22

0.17

0.04

− 0.37*

AQLQ

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

PSQI

0.06

0.04

− 0.01

0.22

0.06

0.18

0.20

− 0.02

0.05

0.23

− 0.01

− 0.33

SIGH-A

− 0.15

− 0.20

− 0.10

0.11

− 0.00

0.02

− 0.10

− 0.29

− 0.05

0.03

0.20

− 0.31

Leukocytes, × 10/9/l

− 0.22

− 0.30

− 0.27

− 0.17

− 0.04

0.08

0.01

− 0.13

− 0.25

0.02

− 0.03

0.09

Eosinophils, × 10/9/l

− 0.14

0.09

0.03

0.01

0.02

− 0.02

0.02

− 0.13

0.02

0.00

− 0.05

− 0.10

Eosinophils, %

− 0.14

0.17

0.06

− 0.06

− 0.02

− 0.06

− 0.02

− 0.16

0.06

− 0.03

− 0.14

− 0.14

Neutrophils, × 10/9/l

− 0.06

− 0.14

− 0.26

0.18

− 0.05

0.09

− 0.06

− 0.17

− 0.28

0.06

− 0.07

0.01

Neutrophils, %

− 0.08

0.20

− 0.16

0.23

− 0.02

0.15

− 0.08

− 0.17

− 0.16

0.24

− 0.07

− 0.12

Eosinophils in nasal smear, %

− 0.14

0.24

− 0.03

0.07

0.03

− 0.01

− 0.13

− 0.05

0.05

− 0.12

− 0.15

− 0.20

Total IgE, kU/l

0.02

− 0.13

0.30

0.20

0.30

0.24

0.36*

− 0.03

0.30

0.18

0.33

0.45

Vitamin D, IU/ml

0.015

0.17

0.05

− 0.10

0.02

− 0.02

− 0.10

− 0.01

0.12

− 0.02

0.11

0.15

FEV1, l, mean ± SEM

0.42*

− 0.06

0.31

0.18

0.10

0.13

0.40*

0.12

0.08

0.17

0.30

0.05

Patients with AR and AA

TNSS

− 0.16

0.02

− 0.01

− 0.09

− 0.35

− 0.17

− 0.40

0.31

− 0.31

− 0.10

0.08

0.26

ACT

0.20

0.26

− 0.22

0.37

0.25

0.44

0.12

− 0.04

0.36

0.25

0.31

0.34

RQLQ

− 0.32

0.26

0.08

− 0.21

− 0.49

− 0.33

− 0.20

0.21

− 0.40*

− 0.14

− 0.03

0.13

AQLQ

0.25

− 0.15

− 0.01

0.40

0.47

0.40

0.24

0.11

0.38

0.40

0.35

− 0.06

PSQI

− 0.52*

0.64*

− 0.40

0.18

− 0.34

− 0.15

− 0.12

− 0.35

− 0.46

0.03

− 0.16

0.30

SIGH-A

− 0.21

0.32

0.00

− 0.08

− 0.11

− 0.33

− 0.18

− 0.14

− 0.38

0.15

-0.18

0.16

Leukocytes, × 10/9/l

0.19

− 0.25

0.28

− 0.08

0.52*

− 0.17

0.29

− 0.08

− 0.10

0.04

0.20

0.19

Eosinophils, × 10/9/l

0.27

− 0.30

0.22

− 0.21

0.31

− 0.13

0.25

0.35

− 0.03

0.14

− 0.07

− 0.12

Eosinophils, %

0.11

− 0.40

0.01

− 0.27

0.10

− 0.16

0.12

0.32

0.01

0.18

− 0.23

− 0.34

Neutrophils, × 10/9/l

0.02

− 0.03

0.21

0.08

0.44*

− 0.10

0.17

− 0.14

− 0.06

− 0.09

0.10

0.33

Neutrophils, %

− 0.08

0.00

0.18

0.25

0.30

0.10

0.17

− 0.26

0.23

0.23

− 0.03

0.25

Eosinophils in nasal smear, %

0.21

− 0.46

0.25

− 0.51*

0.31

− 0.19

0.14

0.38

− 0.05

− 0.33

− 0.03

0.12

Total IgE, kU/l

0.18

− 0.12

0.74**

0.25

0.35

0.23

− 0.09

− 0.17

− 0.16

− 0.00

0.33

0.20

Vitamin D, IU/ml

0.13

− 0.16

− 0.07

− 0.05

− 0.25

0.17

− 0.32

0.21

− 0.12

− 0.29

− 0.04

− 0.07

FEV1, l, mean ± SEM

0.08

− 0.16

− 0.03

0.33

− 0.14

0.40

0.56*

0.11

0.48

0.38

0.10

− 0.16

  1. *p < 0.05, **p < 0.01