Fig. 3

Levels of TNF-a in broncho-alveolar lavage fluid (a); levels of IL-6 in bronchoalveolar lavage fluid (b), the expression of TNF-a and IL-6 in group C and L was significantly lower than that in group H, after the intervention of T-5224, the expression of TNF-a protein decreased significantly. C: Control group, Tidal volume (TV): 0; L: low tidal volume group, VT: 7 ml/kg; H: High tidal volume group, TV: 30 ml/kg; D: DMSO group, V: 30 ml/kg, Half an hour before making the model, the DMSO was injected; T: T-5224 group, TV: 30 ml/kg, Half an hour before making the model, the T-5224 was injected. Half an hour before making the model, the T-5224 was injected, T1 (0.3 mg/kg), T2 (3 mg/kg). Data are expressed as the mean ± SD (n = 6 Rat/group). ****P < 0.0001 versus C;***P < 0.001 versus C; ####P < 0.0001 versus H; ##P < 0.01 versus H