Skip to main content

Table 2 Genetic alterations in accordance with the gender, smoking habit, and age of the patients tested

From: Global prognostic impact of driver genetic alterations in patients with lung adenocarcinoma: a real-life study

Males

Females

p

Never smokers

Ever smokers

p

Age ≤ 50

Age > 50

p

EGFR (n = 1282)

62/848 (7.3%)

114/434 (26.3)

< 0.0001

62/140 (44.3%)

114/641 (17.8%)

< 0.0001

18/100 (18%)

158/1182 (13.4%)

0.2537

KRAS (n = 944)

156/619 (25.2%)

45/325 (13.8%)

0.0001

14/133 (10.5%)

187/585 (32%)

< 0.0001

18/83 (21.7%)

183/861 (21.2%)

0.9613

BRAF (n = 944)

20/619 (3.2%)

8/325 (2.5%)

0.6453

2/133 (1.5%)

26/585 (4.4%)

0.1825

2/83 (2.4%)

26/861 (3%)

0.9794

ALK (n = 880)

26/592 (4.4%)

15/288 (5.2%)

0.7123

5/82 (6.1%)

36/398 (9%)

0.5140

6/57 (10.5%)

35/823 (4.2%)

0.0645

MET (n = 692)

5/471 (1%)

9/221 (4.1%)

0.0247

2/75 (2.7%)

12/345 (3.5%)

1.000

0/46 (0%)

14/646 (2.1%)

0.6883

  1. Statistically significant values (p < 0.05) are evidenced in bold