Table 1 Characteristics of hospitalized COVID-19 patients treated with or without Methylprednisolone (n = 759)
Level | No methylprednisolone (n = 380) | Methylprednisolone (n = 379) | P value |
|---|---|---|---|
Count (%) | Count (%) | ||
Age in years | 65 (54, 80) | 64 (55, 74) | 0.0230 |
Age ≥ 60 years | 254 (66.67) | 244 (64.55) | 0.2436 |
Male | 237 (62.20) | 242 (64.02) | 0.5775 |
Weight (kg) | 81.67 (70.30, 96.00) | 83.90 (71.70, 99.80) | 0.8758 |
BMI ≥ 30 kg/m2 | 179 (46.98) | 181 (47.88) | 0.6767 |
Black | 58 (15.30) | 44 (11.80) | 0.2500 |
White | 178 (46.97) | 160 (42.90) | 0.2500 |
Asian/Indian | 25 (6.60) | 133 (35.66) | 0.2500 |
Hispanic | 118 (31.13) | 181 (47.88) | 0.2500 |
Non-smoker | 278 (78.31) | 251 (74.04) | 0.2334 |
Smoker (former or current) | 77 (21.69) | 88 (25.96) | 0.2334 |
Fever | 250 (65.79) | 294 (77.78) | 0.0003 |
Shortness of breath | 248 (65.09) | 298 (79.05) | < .0001 |
Cough | 242 (63.68) | 270 (71.43) | 0.0191 |
Altered mental status | 63 (16.54) | 41 (10.85) | 0.0032 |
GI | 76 (20.00) | 81 (21.49) | 0.5211 |
Anosmia or ageusia | 6 (1.59) | 9 (2.45) | 0.5930 |
Duration of symptoms PTA in days | 5.00 (2.00, 7.00) | 5.00 (3.00, 7.00) | 0.0699 |
Diabetes | 143 (37.53) | 138 (36.51) | 0.6521 |
COPD | 20 (5.25) | 28 (7.41) | 0.2482 |
Asthma | 24 (6.30) | 37 (9.81) | 0.0741 |
Hypertension | 225 (59.06) | 219 (57.94) | 0.5525 |
Cancer | 43 (11.29) | 43 (11.38) | 0.9013 |
Cerebrovascular accident | 18 (4.74) | 14 (3.70) | 0.3692 |
Coronary artery disease | 29 (7.61) | 28 (7.41) | 0.8886 |
Arrhythmia | 41 (10.79) | 30 (7.94) | 0.1213 |
Renal failure | 28 (7.35) | 31 (8.20) | 0.6682 |
Rheumatologic disorder | 10 (2.62) | 19 (5.04) | 0.0588 |
qSOFA 0 | 224 (58.49) | 222 (58.42) | 0.7647 |
qSOFA 1 | 130 (33.94) | 130 (34.21) | 0.7647 |
qSOFA 2 | 28 (7.31) | 26 (6.84) | 0.7647 |
qSOFA 3 | 1 (0.26) | 2 (0.53) | 0.7647 |
Temperature | 98.80 (97.70, 100.40) | 99.30 (98.00, 100.70) | 0.1284 |
Heart rate | 95.00 (84.00, 108.00) | 97.00 (86.00, 108.00) | 0.1438 |
Arterial pressure | 92.33 (83.33, 100.50) | 90.67 (81.83, 99.33) | 0.0870 |
Respiratory rate | 19.00 (18.00, 22.00) | 20.00 (18.00, 22.00) | 0.3231 |
O2 Sat < 94% | 215 (56.43) | 217 (57.41) | 0.6733 |
Nasal cannula | 160 (82.05) | 131 (65.83) | 0.2500 |
High flow | 6 (3.08) | 15 (7.54) | 0.2500 |
CPAP | 1 (0.51) | 2 (1.01) | 0.2500 |
BiPAP | 0 (0.00) | 2 (1.01) | 0.2500 |
Non-rebreather | 26 (13.33) | 46 (23.12) | 0.2500 |
Mechanical ventilation | 35 (11.15) | 129 (39.33) | < .0001 |
WBC | 6.65 (5.10, 9.20) | 6.50 (5.10, 9.50) | 1.0000 |
HGB | 13.40 (12.30, 14.50) | 13.50 (12.20, 14.70) | 0.6746 |
PLT | 203.00 (161.00, 257.00) | 189.00 (147.00, 252.00) | 0.2736 |
ALC | 0.90 (0.60, 1.30) | 0.80 (0.60, 1.10) | 0.0031 |
IL6 | 12.00 (5.00, 39.00) | 15.00 (5.00, 36.00) | 0.2678 |
CRP | 9.88 (4.99, 17.31) | 12.67 (6.84, 19.08) | 0.0047 |
D-dimer | 1.09 (0.65, 2.20) | 1.44 (0.72, 3.13) | 0.1155 |
Ferritin | 729.50 (325.50, 1404.00) | 867.00 (418.00, 1548.00) | 0.0675 |
Creatinine | 1.01 (0.80, 1.50) | 1.01 (0.80, 1.35) | 0.2630 |
Troponin | 0.03 (0.01, 0.30) | 0.02 (0.01, 0.09) | 0.0732 |
BNP | 131.85 (40.30, 1000.55) | 88.80 (26.20, 362.00) | 0.2110 |
Hydroxychloroquine | 269 (71.93) | 317 (88.55) | < .0001 |
Azithromycin | 255 (68.55) | 264 (73.54) | 0.0728 |
Remdesivir | 3 (0.82) | 10 (2.82) | 0.0196 |
Tocilizumab | 13 (3.53) | 63 (17.65) | < .0001 |
Convalescent plasma | 0 (0.00) | 4 (28.57) | < .0001 |