Table 3 Comparison of the characteristics according to 28-day mortality
| Â | The 28-day survivor | The 28-day non-survivor | p-value | Multivariate analysis | |
|---|---|---|---|---|---|
N = 74 (62.2%) | N = 45 (37.8%) | OR (95% CI) | p-value | ||
Median age | 60.9 (57–72) | 64 (55.5–71.5) | 0.587 |  |  |
Sex (male) | 48 (64.9) | 28 (62.2) | 0.771 | 0.585(0.193–1.779) | 0.345 |
Height, cm | 164.0 (156.0– 170.0) | 161.8 (156.0– 168) | 0.616 |  |  |
BMI, kg/m2 | 22.4 (20.4–25.4) | 22.1 (19.8–24.1) | 0.511 |  |  |
Ever smoker | 21 (28.4) | 13 (28.9) | 0.952 | Â | Â |
Charlson Comorbidity Index | 3 (2– 4) | 3 (2– 5.5) | 0.281 |  |  |
Comorbidity disease | |||||
 Congestive heart failure | 4 (5.4) | 7 (15.6) | 0.100 |  |  |
 Chronic lung disease—airway | 4 (5.4) | 5 (11.1) | 0.296 |  |  |
 Chronic lung disease—ILD | 15 (20.3) | 7 (15.6) | 0.521 |  |  |
 Chronic kidney disease | 17 (23) | 14 (31.1) | 0.327 |  |  |
 Chronic liver disease | 6 (8.1) | 3 (6.7) | 1.0 |  |  |
 Solid cancer | 21 (28.4) | 16 (35.6) | 0.412 |  |  |
 Hematologic malignancy | 12 (16.2) | 10 (22.2) | 0.413 |  |  |
CRRT due to AKI | 17 (23) | 24 (53.3) | 0.001 | 6.645(1.967–22.446 | 0.002 |
Clinical parameters | |||||
 WBC, × 103/μL | 10.8 (6.8–15.7) | 8.5 (4.0–14.6) | 0.070 |  |  |
 Hct, % | 28.0 (24.9–32.6) | 25.6 (22.9–29.6) | 0.045 |  |  |
 Platelet, × 103/μL | 153.5 (79.5–263) | 79 (28–179) | 0.001 | 1.001(0.996–1.007) | 0.658 |
 BUN, mg/dL | 27.2 (18.6–39.4) | 35.2 (22.9–52.0) | 0.069 |  |  |
 Creatinine, mg/dL | 1.1 (0.6–1.8) | 1.1 (0.6–2) | 0.810 |  |  |
 Albumin, g/dL | 2.5 (2.3–2.7) | 2.3 (2.0–2.6) | 0.082 |  |  |
 Total bilirubin, mg/dL | 0.5 (0.3–1.0) | 0.9 (0.4–3.4) | 0.019 | 0.927(0.803–1.071) | 0.304 |
 Sodium, mmol/L | 135 (132–138) | 139.5 (132.8– 141.8) | 0.248 |  |  |
 Potassium, mmol/L | 4.4 (3.6–5.0) | 4.4 (3.8–5.0) | 0.855 |  |  |
 Lactate, mmol/L | 1.8 (1.2–4.3) | 3.1 (1.5–13.1) | 0.054 |  |  |
 Procalcitonin, ng/mL | 1.4 (0.3–5.1) | 1.4 (0.3–10.9) | 0.556 |  |  |
 C-reactive protein, mg/L | 113.6 (50.4–182.1) | 137.9 (71.7–227.8) | 0.253 |  |  |
 PaO2/FiO2 ratio at admission day | 79.2 (64.9–107.8) | 86.4 (65.3–108.3) | 0.569 |  |  |
 PaO2/FiO2 ratio at 3-day after admission | 189.0 (133.3–278.9) | 134.6 (88.0–212.0) | 0.006 | 1.004(0.995–1.014) | 0.371 |
 PaO2 at admission day | 93.3 (74.7–121.3) | 81.9 (69.4–107.9) | 0.268 |  |  |
 PaO2 at 3-day after admission | 82.3 (73.9–107.0) | 76.2 (64.9–95.6) | 0.092 |  |  |
 A-a gradient at admission day | 291.7 (165.1–426.2) | 317.4 (190.7–488.6) | 0.391 |  |  |
 A-a gradient at 3-day after admission | 162.7 (117.9–297.5) | 309.7 (152.2–404.3) | 0.005 | 1.000(0.993–1.007) | 0.952 |
APACHE II score | 25 (19.0–30.0) | 28.5 (22.5–37.0) | 0.045 | 0.998(0.929–1.073) | 0.959 |
SOFA score | 7 (6–9) | 10 (8–13) |  < 0.001 | 0.871(0.696–1.090) | 0.226 |
SAPS II | 35.0 (27–45.5) | 44 (33–54) | 0.015 |  |  |
Pneumothorax | 15 (20.3%) | 7 (15.6%) | 0.521 | Â | Â |
Bacterial respiratory infection | 9 (12.2) | 6 (13.3) | 0.852 | Â | Â |
Fungal respiratory infection | 3 (4.1) | 4 (8.9) | 0.424 | Â | Â |
Cytomegalovirus antigenemia | 51 (68.9) | 24 (53.3) | 0.088 | Â | Â |
Mechanical ventilator parameters | |||||
 Respiratory rate, /min | 20 (16.0–25.3) | 20 (18.0–24.0) | 0.535 |  |  |
 Tidal volume at admission day, mL/kg | 380.0 (320.0–400.0) | 350 (300.0–380.0) | 0.831 |  |  |
 Peak pressure at admission day, cmH2O | 27.0 (20.8–32.0) | 26.0 (23.0–33.0) | 0.988 |  |  |
 Peak pressure at 3-day after admission, cmH2O | 25.0 (19.0–31.3) | 31.0 (27.0–41.0) | 0.003 | 0.998(0.861–1.158) | 0.983 |
 Maximal peak pressure, cmH2O | 30.0 (24.5–35.5) | 36.0 (29.0–42.0) | 0.009 | 0.911(0.786–1.056) | 0.217 |
 Positive expiratory end pressure, cmH2O | 5.0 (5.0–8.0) | 7.0 (5.0–10.0) | 0.328 |  |  |
 Dynamic driving pressure, cmH2O | 18.0 (14.8–22.3) | 17.0 (14.0–22.0) | 0.777 |  |  |