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Table 2 Multivariable-adjusted odds ratios of potential risk factors for low DLCO

From: The association between transfer coefficient of the lung and the risk of exacerbation in asthma-COPD overlap: an observational cohort study

Variables Number of events/cases (%) Multivariable-adjusted OR (95% CI) P value
  Exposure group Reference group   
Male gender 21/77 (27.3%) 8/17 (47.3%) 0.90 (0.18–4.40) 0.89
Age (per 10-year increase) N/A N/A 0.83 (0.41–1.66) 0.60
BMI (per 1 kg/m2 increase) N/A N/A 1.03 (0.86–1.22) 0.76
FEV1 (per 1 L increase) N/A N/A 0.29 (0.10–0.76) 0.02
Inhaled long-acting bronchodilator use 22/68 (32.4%) 7/26 (26.9%) 8.42 (0.93–108) 0.07
ICS use 17/64 (26.6%) 12/30 (40.0%) 0.07 (0.01–0.59) 0.02
COPD-like features     
Smoking history ≥ 10 pack-years 28/87 (32.2%) 1/7 (14.3%) 3.32 (0.34–80.7) 0.36
Emphysema 22/64 (34.4%) 7/30 (23.3%) 1.32 (0.39–4.77) 0.66
Asthmatic features     
Eosinophilic component 18/56 (32.1%) 11/38 (28.9%) 1.65 (0.51–5.71) 0.41
High FeNO 11/44 (25.0%) 18/50 (36.0%) 0.51 (0.15–1.61) 0.26
Positive levels for total IgE and/or IgE specific to perennial inhalant antigens 21/75 (28.0%) 8/19 (42.1%) 0.51 (0.12–2.06) 0.34
Bronchial reversibility 5/18 (27.8%) 24/76 (31.6%) 1.08 (0.24–4.20) 0.92
  1. Adjustment was made for age, gender, BMI, FEV1, long-acting bronchodilator use, ICS use, a smoking history of > 10 pack-years, emphysema, high FeNO, bronchial reversibility, an eosinophilic component, and positive levels for total IgE and/or IgE specific to perennial inhalant antigens. The eosinophilic component was defined as blood eosinophil ≥ 5% and/or ≥ 300/µl. High FeNO was defined as ≥ 35 parts per billion. Bronchial reversibility was defined as ≥ 12% and ≥ 200 ml reversibility in post-bronchodilator FEV1. Positive levels for total IgE were defined as > 170 IU/ml
  2. OR, odds ratio; 95% CI, 95% confidence interval; BMI, body mass index; FEV1, forced expiratory volume in 1 s; ICS, inhaled corticosteroid; COPD, chronic obstructive pulmonary disease; N/A, not applicable