Fig. 5

LMCD1-AS1 accelerates NSCLC cell proliferation, migration and invasion through the regulation of OSBPL5. A The mRNA and protein levels of OSBPL5 in NSCLC cells were tested by qRT-PCR and western blot analyses. *P < 0.05. B, C Cell viability and proliferation in A549 cells after transfection of sh-NC, sh- LMCD1-AS1, or sh-LMCD1-AS1 + pcDNA3.1 OSBPL5 was measured by CCK-8 and EdU assays, respectively. *P < 0.05. D, E Cell migration and invasion in A549 cells after transfection of indicated plasmids were evaluated by Transwell assays. *P < 0.05. F EMT process-associated protein (E-cadherin, N-cadherin and Vimentin) expressions in A549 cells in the three groups were detected by western blot analysis. *P < 0.05