Concurrent chemoradiotherapy with cisplatin + S-1 versus cisplatin + other third-generation agents for locally advanced non-small-cell lung cancer: a meta-analysis of individual participant data

Table 5 Toxicities

Adverse effect	SP (N = 159)		Non-SP (N = 157)		p-value
Adverse effect	All grade	Grade 3–4	All grade	Grade 3–4	Grade 3–4
Leukopenia	148	59	153	103	< 0.001
Neutropenia	139	53	146	97	< 0.001
Thrombocytopenia	108	7	86	8	0.797
Anemia	143	23	150	28	0.447
Febrile neutropenia	11	11	16	16	0.321
AST increased	49	0	46	2	0.246
ALT increased	68	2	70	7	0.102
Creatinine increased	42	1	55	0	1.000
Hyponatremia	91	18	81	11	0.242
Nausea	102	3	118	9	0.084
Vomiting	23	2	34	1	1.000
Anorexia	119	16	128	26	0.099
Diarrhea	47	9	30	2	0.060
Esophagitis	107	7	107	6	1.000
Pneumonitis	35	7	36	9	0.618
Alopecia	9	0	51	0	–

SP, S-1 + cisplatin; AST, Aspartate aminotransferase; ALT, Alanine aminotransferase

ISSN: 1471-2466