Variable | Needing IMV (n = 99) | Weaning from IMV (n = 796) | p Value |
---|---|---|---|
Age ≥ 65 years old (n, %) # | 66 (66.7) | 334 (42.0) | < 0.001 |
Male (n, %) | 55 (55.6) | 421 (52.9) | 0.616 |
Influenza A infection (n, %) # | 72 (72.7) | 471 (59.2) | 0.009 |
Comorbidities (n, %) | |||
Cardiovascular disease | 26 (26.3) | 176 (22.1) | 0.351 |
Diabetes mellitus | 11 (11.1) | 102 (12.8) | 0.630 |
Cerebrovascular disease | 9 (9.1) | 78 (9.8) | 0.823 |
COPD | 10 (10.1) | 75 (9.4) | 0.828 |
Chronic kidney disease | 0 (0.0) | 29 (3.6) | 0.103 |
Asthma | 1 (1.0) | 23 (2.9) | 0.446 |
Solid Malignant tumor # | 8 (8.1) | 13 (1.6) | < 0.001 |
Pregnancy (n, %) | 0 (0.0) | 6 (0.8) | 1.000 |
Obesity (n, %) | 4 (4.0) | 53 (6.7) | 0.314 |
Smoking history (n, %) | 24 (24.2) | 215 (27.0) | 0.557 |
Baseline clinical and radiologic features (n, %) | |||
Mental confusion | 15 (15.2) | 96 (12.1) | 0.379 |
Respiratory rates ≥ 30 breaths/min # | 54 (54.5) | 77 (9.7) | < 0.001 |
SBP < 90 mmHg | 1 (1.0) | 6 (0.8) | 0.561 |
Leukocytes > 10 × 109/L # | 14 (14.1) | 203 (25.5) | 0.013 |
Lymphocytes < 0.8 × 109/L # | 67 (67.7) | 312 (39.2) | < 0.001 |
HB < 100 g/L | 18 (18.2) | 179 (22.5) | 0.329 |
ALB < 35 g/L # | 10 (10.1) | 153 (19.2) | 0.014 |
BUN > 7 mmol/L | 35 (35.4) | 316 (39.7) | 0.386 |
BG > 14 mmol/L | 0 (0.0) | 8 (1.0) | 0.606 |
Arterial PH < 7.35 # | 21 (22.2) | 67 (8.4) | 0.001 |
PaO2/FiO2 < 300 mmHg # | 81 (81.8) | 351 (44.1) | < 0.001 |
PaCO2 > 50 mmHg | 7 (7.1) | 82 (10.3) | 0.133 |
Multilobar infiltrates # | 77 (77.8) | 558 (70.1) | 0.113 |
Pleural effusion | 27 (27.3) | 251 (31.5) | 0.388 |
Coinfections (n, %) | 32 (32.3) | 270 (33.9) | 0.751 |
Early NAI therapy (n, %) # | 17 (17.2) | 294 (36.9) | < 0.001 |
Systemic corticosteroids use at admission (n, %) # | 21 (21.2) | 32 (4.0) | < 0.001 |
Noninvasive ventilation within 14 days after admission (n, %) | 17 (17.2) | 94 (11.8) | 0.127 |