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Table 1 Comparison of clinical characteristics and outcomes between patients needing and weaning from IMV from derivation cohort

From: Flu-IV score: a predictive tool for assessing the risk of invasive mechanical ventilation in patients with influenza-related pneumonia

Variable

Needing IMV

(n = 99)

Weaning from IMV

(n = 796)

p Value

Age ≥ 65 years old (n, %) #

66 (66.7)

334 (42.0)

 < 0.001

Male (n, %)

55 (55.6)

421 (52.9)

0.616

Influenza A infection (n, %) #

72 (72.7)

471 (59.2)

0.009

Comorbidities (n, %)

 Cardiovascular disease

26 (26.3)

176 (22.1)

0.351

 Diabetes mellitus

11 (11.1)

102 (12.8)

0.630

 Cerebrovascular disease

9 (9.1)

78 (9.8)

0.823

 COPD

10 (10.1)

75 (9.4)

0.828

 Chronic kidney disease

0 (0.0)

29 (3.6)

0.103

 Asthma

1 (1.0)

23 (2.9)

0.446

 Solid Malignant tumor #

8 (8.1)

13 (1.6)

 < 0.001

Pregnancy (n, %)

0 (0.0)

6 (0.8)

1.000

Obesity (n, %)

4 (4.0)

53 (6.7)

0.314

Smoking history (n, %)

24 (24.2)

215 (27.0)

0.557

Baseline clinical and radiologic features (n, %)

 Mental confusion

15 (15.2)

96 (12.1)

0.379

 Respiratory rates ≥ 30 breaths/min #

54 (54.5)

77 (9.7)

 < 0.001

 SBP < 90 mmHg

1 (1.0)

6 (0.8)

0.561

 Leukocytes > 10 × 109/L #

14 (14.1)

203 (25.5)

0.013

 Lymphocytes < 0.8 × 109/L #

67 (67.7)

312 (39.2)

 < 0.001

 HB < 100 g/L

18 (18.2)

179 (22.5)

0.329

 ALB < 35 g/L #

10 (10.1)

153 (19.2)

0.014

 BUN > 7 mmol/L

35 (35.4)

316 (39.7)

0.386

 BG > 14 mmol/L

0 (0.0)

8 (1.0)

0.606

 Arterial PH < 7.35 #

21 (22.2)

67 (8.4)

0.001

 PaO2/FiO2 < 300 mmHg #

81 (81.8)

351 (44.1)

 < 0.001

 PaCO2 > 50 mmHg

7 (7.1)

82 (10.3)

0.133

Multilobar infiltrates #

77 (77.8)

558 (70.1)

0.113

Pleural effusion

27 (27.3)

251 (31.5)

0.388

Coinfections (n, %)

32 (32.3)

270 (33.9)

0.751

Early NAI therapy (n, %) #

17 (17.2)

294 (36.9)

 < 0.001

Systemic corticosteroids use at admission (n, %) #

21 (21.2)

32 (4.0)

 < 0.001

Noninvasive ventilation within 14 days after admission (n, %)

17 (17.2)

94 (11.8)

0.127

  1. IMV invasive mechanical ventilation, NIMV noninvasive mechanical ventilation, COPD chronic obstructive pulmonary disease, SBP systolic blood pressure, HB hemoglobin, ALB albumin, BUN blood urea nitrogen, BG blood glucose, PaO2/FiO2 arterial pressure of oxygen/fraction of inspiration oxygen, NAI neuraminidase inhibitor. #: variables cited in the table above were the candidates which were entered into the multivariate logistic regression model. The bolded values are p values < 0.05, which represented significant differences between patients needing and free of invasive ventilation