Characteristics | Total | LAP+ | LAP− | p |
---|---|---|---|---|
(N = 48) | (N = 23) | (N = 25) | ||
Epidemiological | ||||
Female sex (%) | 30 (62.5) | 9 (39.1) | 21 (84) | 0.002 |
Age in mean* ± SD (years) | 52 ± 14 | 51 ± 10 | 53 ± 14 | NS |
Mean disease duration ± SD (years) | 2.5 ± 4.1 | 2.3 ± 4.1 | 2.8 ± 4.2 | NS |
Silica exposure (%) | 8 (16.7) | 8 (34.8) | 0 (0) | 0.001 |
Tobacco exposure** (%) | 14 (29.2) | 8 (34.8) | 6 (24) | NS |
Phenotype | ||||
GERD (%) | 47 (97.9) | 22 (95.7) | 25 (100) | NS |
Intestinal involvement (%) | 7 (14.6) | 4 (17.4) | 3 (12) | NS |
Ano-rectal involvement (%) | 5 (10.4) | 1 (4.4) | 4 (16) | NS |
Joint involvement (fingers/hands/wrists) (%) | 21 (43.7) | 11 (47.8) | 20 (80) | 0.03 |
Muscular involvement (%) | 4 (8.3) | 1 (4.4) | 3 (12) | NS |
Raynaud’s phenomenon (%) | 46 (95.8) | 22 (95.7) | 25 (100) | NS |
Digital ulcer (%) | 26 (54.2) | 11 (47.8) | 15 (60) | NS |
Cutaneous calcinosis (%) | 10 (20.8) | 3 (13) | 7 (28) | NS |
Telangiectasia (%) | 29 (60.4) | 15 (60) | 14 (56) | NS |
Sicca syndrome (%) | 11 (22.9) | 6 (-26.1) | 5 (20) | NS |
Scleroderma renal crisis (%) | 9 (18.8) | 3 (13) | 6 (24) | NS |
Pericarditis (%) | 5 (10.4) | 1 (4.4) | 4 (16) | NS |
Myocardial involvement (%) | 7 (14.6) | 6 (26.1) | 5 (20) | NS |
Pulmonary hypertension (%) | 5 (10.4) | 3 (13) | 2 (8) | NS |
Group 1 (PAH) (%) | 3 (6.3) | 2 (8.9) | 1 (4) | NS |
Group 3 (%) | 2 (4.2) | 2 (8.9) | 0 (0) | NS |
Rodnan score*** ± SD | 23 ± 8 | 22 ± 7.6 | 24 ± 8.4 | NS |
ILD (%) | 30 (-62.5) | 15 (65.2) | 15 (60) | NS |
Immunological | ||||
Anti-Scl70 antibody (%) | 26 (54.2) | 16 (69.6) | 10 (40) | 0.078 |
Anti-centromere antibody (%) | 2 (4.2) | 1 (4.4) | 1 (4) | NS |
Anti-RNA polymerase III antibody (%) | 4 (8.3) | 0 (0) | 4 (16) | NS |
Anti-U1RNP antibody (%) | 3 (6.3) | 0 (0) | 3 (12) | NS |
No antibody specificity (%) | 15 (31.3) | 6 (26.1) | 9 (36) | NS |
Mean CRP level in mg/L♦ ± SD | 18 ± 20 | 22 ± 19.8 | 15 ± 20.1 | NS |
Pulmonary function test♦♦ | ||||
Mean FVC in mL ± SD | 3024 ± 985 | 3185 ± 1025 | 2981 ± 953 | NS |
Mean DLCO in % ± SD | 65 ± 22 | 61 ± 21 | 71 ± 21 | NS |