Table 2 Biosampling and laboratory analyses in IRIS
From: IRIS: Infection with RespIratory Syncytial Virus in infants—a prospective observational cohort study
Source | Specimen | Direct analysis | Biobank sampling; planned analyses |
|---|---|---|---|
Upper airway tract | Nasopharyngeal aspirate or swab | PCR pathogen screening, microbiome analysis, culture (optional) | Yes; sequencing and cultures of clinical viral strains |
Upper airway tract | Nasal fluid | Yes; cytokine analyses, transcriptome, microRNA analysis | |
Blood | EDTA | Optional: differential blood count | Yes; flow cytometry, chip-cytometry, genomics, epigenomics |
Blood | Serum | Optional: CRP, creatinin, sodium, urea, blood gas | Yes; proteomics, metabolome, antibody-screening |
Blood | Plasma | Yes; microRNA, metabolome |