Table 1 Clinical characteristics of the patients with acute respiratory distress syndrome, categorized according to prone positioning response and survival
Characteristics | Response to prone positioning | Survival | ||||
|---|---|---|---|---|---|---|
Responders (n = 68) | Nonresponders (n = 28) | p value†| Survivors (n = 44) | Nonsurvivors (n = 52) | p value‡ | |
Age, years | 66.9 ± 15.8 | 64.4 ± 16.9 | 0.501 | 65.7 ± 16.7 | 66.5 ± 15.6 | 0.803 |
Male sex | 41 (60.3) | 15 (53.6) | 0.544 | 30 (68.2) | 26 (0.5) | 0.072 |
Body mass index | 23.7 ± 4.2 | 25.2 ± 6.7 | 0.189 | 25.2 ± 5.9 | 23.2 ± 4.15 | 0.054 |
Etiology of ARDS | ||||||
Pneumonia | 30 (44.1) | 13 (46.4) | 0.836 | 20 (45.5) | 23 (44.2) | 0.904 |
Aspiration | 14 (20.6) | 4 (14.3) | 0.472 | 9 (20.5) | 9 (17.3) | 0.694 |
Sepsis | 13 (19.2) | 5 (17.9) | 0.886 | 8 (18.2) | 10 (19.2) | 0.896 |
Other | 11 (16.2) | 6 (21.4) | 0.540 | 7 (15.9) | 10 (19.2) | 0.671 |
Comorbidity | ||||||
Remote stroke | 13 (19.1) | 2 (7.1) | 0.142 | 10 (22.7) | 5 (9.6) | 0.080 |
Cardiovascular disease | 17 (25) | 4 (14.3) | 0.248 | 11 (25) | 10 (19.2) | 0.496 |
Chronic kidney disease | 1 (1.5) | 9 (32.1) | 0.159 | 6 (13.6) | 4 (7.7) | 0.342 |
Diabetes mellitus | 36 (52.9) | 12 (42.9) | 0.369 | 25 (56.8) | 23 (44.2) | 0.219 |
Cancer | 25 (36.8) | 8 (28.6) | 0.442 | 11 (25) | 22 (42.3) | 0.075 |
Immunocompromised | 11 (16.2) | 5 (17.9) | 0.841 | 5 (11.4) | 11 (21.2) | 0.200 |
Hepatic disease | 4 (5.9) | 2 (7.1) | 0.817 | 3 (6.8) | 3 (5.8) | 0.832 |
Pulmonary disease | 8 (11.2) | 7 (25) | 0.105 | 9 (20.5) | 6 (11.5) | 0.231 |
Respiratory mechanics | ||||||
Tidal volume (ml) | 448.8 ± 155.4 | 437.6 ± 108.2 | 0.731 | 421.9 ± 103.6 | 465.5 ± 167.4 | 0.137 |
Tidal volume (ml/kg of PBW) | 7.9 ± 2.7 | 8.2 ± 7.3 | 0.550 | 7.4 ± 1.9 | 8.4 ± 2.9 | 0.160 |
Respiratory frequency (breathes/min) | 23.0 ± 4.7 | 22.5 ± 6.0 | 0.655 | 21.9 ± 4.8 | 23.6 ± 5.3 | 0.110 |
Dynamic driving pressure (cmH2O) | 15.3 ± 2.7 | 15.7 ± 4.1 | 0.594 | 15.1 ± 3.2 | 15.6 ± 3.2 | 0.449 |
PEEP (cmH2O) | 11.8 ± 2.5 | 12.0 ± 2.0 | 0.745 | 12.2 ± 2.5 | 11.6 ± 2.3 | 0.186 |
Plateau pressure (cmH2O) | 27.2 ± 3.5 | 27.6 ± 3.6 | 0.485 | 27.5 ± 4.2 | 27.4 ± 2.9 | 0.836 |
Mean airway pressure (cmH2O) | 17.7 ± 2.9 | 17.9 ± 2.5 | 0.422 | 17.8 ± 2.9 | 17.8 ± 2.7 | 0.136 |
Compliance (mL/cmH2O) | 30.6 ± 12.6 | 30.6 ± 12.7 | 0.998 | 29.6 ± 11.6 | 31.5 ± 13.5 | 0.452 |
Mechanical power (J/min) | 26.4 ± 8.3 | 25.5 ± 6.1 | 0.623 | 24.2 ± 6.8 | 27.8 ± 8.1 | 0.021 |
SAPS II score | 52.5 ± 16.9 | 50.9 ± 15.8 | 0.667 | 47.6 ± 12.9 | 55.8 ± 18.3 | 0.016 |
SOFA score | 9.5 ± 3.7 | 9.8 ± 3.5 | 0.733 | 9.1 ± 3.3 | 9.9 ± 3.8 | 0.277 |
Baseline PaO2/FiO2 ratio | 86.4 ± 26.2 | 95.4 ± 26.2 | 0.128 | 92.4 ± 30.3 | 86.2 ± 22.5 | 0.254 |
Vasopressor | 56 (82.4) | 23 (82.1) | 0.980 | 33 (75) | 46 (88.5) | 0.085 |
Total CT-consolidation scores* | 24.5 (14–31) | 21.5 (8–30.5) | 0.278 | 24.5 (12–33) | 23 (12.5–30.5) | 0.699 |
Total CT-GGO scores* | 12.5 (2.5–37.5) | 23.5 (5–46) | 0.376 | 9 (1–26) | 25 (11–46) | 0.001 |