Table 1 Baseline characteristics of all 202 patients stratified by SII before brain radiotherapy
Characteristics | Variables | N (%) | SII | |||
|---|---|---|---|---|---|---|
< 859.79 | ≥ 859.79 | X2 | P | |||
Sex | Female | 129 (63.9) | 72 | 57 | 0.494 | 0.482 |
Male | 73 (36.1) | 37 | 36 | Â | Â | |
Age (years) | < 60 | 140 (69.3) | 77 | 63 | 0.198 | 0.656 |
|  | ≥ 60 | 62 (30.7) | 32 | 30 |  |  |
Smoking status | Never | 158 (78.2) | 87 | 71 | 0.355 | 0.551 |
| Â | Former/current | 44 (21.8) | 22 | 22 | Â | Â |
EGFR mutation | Exon 21 | 93 (46.04) | 46 | 46 | 6.542 | 0.088 |
| Â | Exon 19 | 83 (41.09) | 50 | 33 | Â | Â |
| Â | Other (18 or 20) | 12 (5.94) | 3 | 9 | Â | Â |
| Â | Unclear | 14 (6.93) | 9 | 5 | Â | Â |
Lung-molGPA | 0–2 | 89 (44.1) | 51 | 38 | 0.716 | 0.398 |
|  | 2.5–4 | 113 (55.9) | 58 | 55 |  |  |
Brain radiation mode | WBRT | 76 (37.6) | 44 | 32 | 0.760 | 0.684 |
Local radiotherapy | 89 (44.1) | 46 | 43 | Â | Â | |
WBRT + Boost | 37 (18.3) | 19 | 18 |  |  | |
Thoracic radiation | Yes | 79 (39.1) | 43 | 36 | 0.012 | 0.914 |
| Â | No | 123 (60.9) | 66 | 57 | Â | Â |
Chemotherapy | Yes | 169 (83.7) | 93 | 76 | 0.476 | 0.490 |
| Â | No | 33 (16.3) | 16 | 17 | Â | Â |
Metastatic sites | Lung | 96 (47.5) | 50 | 46 | 1.183 | 0.947 |
| Â | Bone | 129 (63.9) | 66 | 63 | Â | Â |
| Â | Liver | 37 (18.3) | 17 | 20 | Â | Â |
| Â | Adrenal gland | 41 (20.3) | 19 | 22 | Â | Â |
| Â | Pleura | 52 (25.7) | 27 | 25 | Â | Â |
| Â | Others | 30 (14.9) | 17 | 13 | Â | Â |
SII | < 859.79 | 109 (54) | NA | NA | NA | NA |
|  | ≥ 859.79 | 93 (46) | NA | NA |  |  |
Dynamic change of SII | High–high | 59 (29.2) | NA | NA | NA | NA |
|  | High–low | 34 (16.8) | NA | NA |  |  |
|  | Low–low | 67 (33.2) | NA | NA |  |  |
|  | Low–high | 42 (20.8) | NA | NA |  |  |