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Table 1 Clinical, biological and radiological characteristics of patients

From: Immune alveolitis in interstitial lung disease: an attractive cytological profile in immunocompromised patients

Characteristics of patients Total (N = 249)
Clinical
 Age, years 57 ± 16
 Male 140 (56)
 Smoking status
  Smoker (NA = 3) 98 (40)
  Number of pack-years 21 ± 18
 Comorbidities
  Immunocompromised 163 (65)
  Solid cancer 65 (26)
  Hematological cancer 56 (22)
  Solid organ transplant 39 (16)
  Bone marrow transplant 24 (10)
  Connective tissue diseases 20 (8)
  HIV positive 8 (3)
 Treatments
  Corticosteroid 75 (30)
  Dose, mg/day 16.5 ± 16
  Methotrexate 18 (7)
  Mycophenolate mofetil 20 (8)
  Ciclosporin 20 (8)
  Chemotherapy 29 (12)
  Immunotherapy 11 (4)
  Pneumocystis prophylaxis 43 (17)
Radiological
 Lesions on chest CT scan (NA = 21)
  Ground glass opacities 179 (79)
  Reticulation 88 (39)
  Micronodules 66 (29)
  Consolidation 62 (27)
  Septa thickening 37 (16)
  Mosaic attenuation 11 (5)
 Bilateral lesions 197 (86)
 Distribution (NA = 21)
  Diffuse 136 (60)
  Lower lobes 54 (24)
  Upper lobes 32 (14)
Biological
 Serum biology
  Leukocytes, giga/L (NA = 36) 8.0 ± 6.0
  Neutrophils, giga/L (NA = 47) 5.5 ± 4.0
  Lymphocytes, giga/L (NA = 47) 1.6 ± 3.7
  Eosinophils, giga/L (NA = 48) 0.18 ± 0.21
  Hemoglobin, g/dL (NA = 36) 12.1 ± 2.2
  Platelets, giga/L (NA = 39) 278 ± 561
  CRP, mg/dL (NA = 92) 65.4 ± 73.2
 Bronchial fibroscopy
  Bacteria 37 (15)
  Mycobacteria (NA = 4) 7 (3)
  Positive viral PCR (NA = 18) 34 (15)
  Fungi 94 (38)
  Pneumocystis cysts (direct examination) 17 (7)
  Positive Pneumocystis PCR (NA = 75) 89 (51)
  Pneumocystis PCR copies (NA = 4)
   Colonization 32 (38)
   Intermediate 25 (29)
   Infection 28 (33)
 BAL cellularity, cells/ml 245,692 ± 350,317
 Cell populations on BAL, % (NA = 4)
  Macrophages 43 ± 17
  Lymphocytes 51 ± 18
  Neutrophils 5 ± 8
  Eosinophils 1.5 ± 4
 Morphological abnormalities on BAL, (NA = 1)
  Activated lymphocytes 238 (96)
  Macrophages into cohesive clusters 245 (99)
  Epithelioid transformation of macrophages 240 (97)
  Foamy macrophages 185 (75)
  1. Data are presented as mean ± SD or N (%)
  2. BAL bronchoalveolar lavage, SD standard deviation, N number, NA not applicable