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Table 1 Clinical, biological and radiological characteristics of patients

From: Immune alveolitis in interstitial lung disease: an attractive cytological profile in immunocompromised patients

Characteristics of patients

Total (N = 249)

Clinical

 Age, years

57 ± 16

 Male

140 (56)

 Smoking status

  Smoker (NA = 3)

98 (40)

  Number of pack-years

21 ± 18

 Comorbidities

  Immunocompromised

163 (65)

  Solid cancer

65 (26)

  Hematological cancer

56 (22)

  Solid organ transplant

39 (16)

  Bone marrow transplant

24 (10)

  Connective tissue diseases

20 (8)

  HIV positive

8 (3)

 Treatments

  Corticosteroid

75 (30)

  Dose, mg/day

16.5 ± 16

  Methotrexate

18 (7)

  Mycophenolate mofetil

20 (8)

  Ciclosporin

20 (8)

  Chemotherapy

29 (12)

  Immunotherapy

11 (4)

  Pneumocystis prophylaxis

43 (17)

Radiological

 Lesions on chest CT scan (NA = 21)

  Ground glass opacities

179 (79)

  Reticulation

88 (39)

  Micronodules

66 (29)

  Consolidation

62 (27)

  Septa thickening

37 (16)

  Mosaic attenuation

11 (5)

 Bilateral lesions

197 (86)

 Distribution (NA = 21)

  Diffuse

136 (60)

  Lower lobes

54 (24)

  Upper lobes

32 (14)

Biological

 Serum biology

  Leukocytes, giga/L (NA = 36)

8.0 ± 6.0

  Neutrophils, giga/L (NA = 47)

5.5 ± 4.0

  Lymphocytes, giga/L (NA = 47)

1.6 ± 3.7

  Eosinophils, giga/L (NA = 48)

0.18 ± 0.21

  Hemoglobin, g/dL (NA = 36)

12.1 ± 2.2

  Platelets, giga/L (NA = 39)

278 ± 561

  CRP, mg/dL (NA = 92)

65.4 ± 73.2

 Bronchial fibroscopy

  Bacteria

37 (15)

  Mycobacteria (NA = 4)

7 (3)

  Positive viral PCR (NA = 18)

34 (15)

  Fungi

94 (38)

  Pneumocystis cysts (direct examination)

17 (7)

  Positive Pneumocystis PCR (NA = 75)

89 (51)

  Pneumocystis PCR copies (NA = 4)

   Colonization

32 (38)

   Intermediate

25 (29)

   Infection

28 (33)

 BAL cellularity, cells/ml

245,692 ± 350,317

 Cell populations on BAL, % (NA = 4)

  Macrophages

43 ± 17

  Lymphocytes

51 ± 18

  Neutrophils

5 ± 8

  Eosinophils

1.5 ± 4

 Morphological abnormalities on BAL, (NA = 1)

  Activated lymphocytes

238 (96)

  Macrophages into cohesive clusters

245 (99)

  Epithelioid transformation of macrophages

240 (97)

  Foamy macrophages

185 (75)

  1. Data are presented as mean ± SD or N (%)
  2. BAL bronchoalveolar lavage, SD standard deviation, N number, NA not applicable