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Table 2 Primary (SD, CV and PPGE) and secondary outcomes (TIR, TAR, TBR, mean glucose level and glycemic gap) for 40 patients hospitalized for community-acquired pneumonia

From: Glycemic variability assessed by continuous glucose monitoring in hospitalized patients with community-acquired pneumonia

Parameter

Daytime

Parameter

Nighttime

β (95% CI)

P

β (95% CI)

P

Relative change in standard deviation (SD) of all CGM-glucose values per change in explanatory variables

     

Intercept

1.16 (0.92 to 1.46)

 

Intercept

0.71 (0.50 to 1.02)

 

T2DM = yes

1.93 (1.40 to 2.66)

 < 0.001

T2DM = yes

2.29 (1.38 to 3.81)

0.002

GC = yes

1.42 (1.04 to 1.97)

0.031

GC = yes

1.21 (0.73 to 2.01)

0.451

T2DM·GC = yes

1.09 (0.69 to 1.71)

0.717

T2DM·GC = yes

0.91 (0.44 to 1.86)

0.790

Parameter

Daytime

Parameter

Nighttime

β (95% CI)

P

β (95% CI)

P

Absolute change in coefficient of variation (CV) in percentage points per change in explanatory variables

     

Intercept

20.3 (16.7 to 23.8)

 

Intercept

15.0 (10.0 to 20.0)

 

T2DM = yes

5.1 (0.0 to 10.1)

0.046

T2DM = yes

8.1 (1.0 to 15.2)

0.026

GC = yes

0.9 (− 4.1 to 5.9)

0.721

GC = yes

0.5 (− 6.6 to 7.6)

0.887

T2DM·GC = yes

0.9 (− 6.2 to 7.9)

0.805

T2DM·GC = yes

 − 3.8 (− 13.8 to 6.2)

0.444

Parameter

Breakfast

Parameter

Lunch

Parameter

Dinner

β (95% CI)

P

β (95% CI)

P

β (95% CI)

P

Absolute change in post prandial glycemic excursion (PPGE) in mmol/L and mg/dL (at the bottom) per change in explanatory variables

        

Intercept

2.1 (1.3 to 2.9)

38 (23 to 52)

 

Intercept

1.3 (0.6 to 2.0)

23 (11 to 36)

 

Intercept

1.3 (0.3 to 2.2)

23 (5 to 40)

 

T2DM = yes

1.5 (0.4 to 2.7)

27 (7 to 49)

0.018

T2DM = yes

 − 0.3 (− 1.3 to 0.7)

 − 5 (− 23 to 13)

0.602

T2DM = yes

1.4 (− 0.0 to 2.8)

25 (0 to 50)

0.076

GC = yes

0.4 (− 0.9 to 1.7)

7 (− 16 to 31)

0.538

GC = yes

0.3 (− 1.1 to 1.7)

5 (− 20 to 31)

0.671

GC = yes

0.8 (− 0.8 to 2.5)

14 (− 14 to 45)

0.355

T2DM·GC = yes

 − 0.3 (− 2.1 to 1.5)

 − 5 (− 38 to 27)

0.739

T2DM·GC = yes

2.5 (0.7 to 4.3)

45 (13 to 77)

0.018

T2DM·GC = yes

 − 1.1 (− 3.4 to 1.1)

 − 20 (− 61 to 20)

0.332

Parameter

Daytime

Parameter

Nighttime

β (95% CI)

P

β (95% CI)

P

Absolute change in time in range (TIR) in percentage points per change in explanatory variables

     

Intercept

94 (81 to 106)

 

Intercept

88 (73 to 103)

 

T2DM = yes

 − 27 (− 44 to − 9)

0.004

T2DM = yes

 − 2 (− 24 to 19)

0.819

GC = yes

 − 11 (− 29 to 6)

0.196

GC = yes

6 (− 15 to 27)

0.554

T2DM·GC = yes

 − 31 (− 56 to − 6)

0.017

T2DM·GC = yes

 − 33 (− 63 to − 3)

0.032

Parameter

Daytime

Parameter

Nighttime

β (95% CI)

P

β (95% CI)

P

Relative change in time above range (TAR) per change in explanatory variables

     

Intercept

2.55 (1.26 to 5.16)

 

Intercept

0.40 (0.06 to 2.64)

 

T2DM = yes

14.19 (6.09 to 33.06)

 < 0.001

T2DM = yes

42.62 (5.76 to 315.24)

 < 0.001

GC = yes

7.57 (3.25 to 17.64)

 < 0.001

GC = yes

38.24 (4.33 to 337.80)

0.002

T2DM·GC = yes

0.27 (0.09 to 0.80)

0.023

T2DM·GC = yes

0.07 (0.01 to 0.74)

0.034

Parameter

Daytime

Parameter

Nighttime

β (95% CI)

P

β (95% CI)

P

Relative change in time below range (TBR) per change in explanatory variables

     

Intercept

7.39 (3.98 to 13.72)

 

Intercept

  

T2DM = yes

0.16 (0.04 to 0.58)

0.001

T2DM = yes

Model is overparametrized

 

GC = yes

0.21 (0.06 to 0.78)

0.026

GC = yes

  

T2DM·GC = yes

2.07 (0.19 to 22.80)

0.556

T2DM·GC = yes

  

Parameter

Daytime β (95% CI)

Parameter

Nighttime β (95% CI)

mmol/L

mg/dL

P

mmol/L

mg/dL

P

Absolute change in mean glucose level in mmol/L and mg/dL per change in explanatory variables

       

Intercept

6.0 (4.4 to 7.5)

108 (79 to 135)

 

Intercept

5.2 (3.9 to 6.6)

94 (70 to 119)

 

T2DM = yes

3.0 (0.8 to 5.2)

54 (14 to 94)

0.009

T2DM = yes

2.4 (0.4 to 4.3)

44 (7 to 77)

0.018

GC = yes

2.4 (0.1 to 4.6)

43 (2 to 83)

0.038

GC = yes

1.6 (− 0.4 to 3.4)

29 (− 7 to 61)

0.113

T2DM·GC = yes

2.5 (− 0.7 to 5.6)

45 (− 13 to 101)

0.120

T2DM·GC = yes

1.2 (− 1.5 to 3.9)

22 (− 27 to 70)

0.374

Parameter

β (95% CI)

P

mmol/L

mg/dL

Absolute change in glycemic gap in mmol/L and mg/dL per change in explanatory variables

   

Intercept

2.1 (0.9 to 3.2)

38 (16 to 58)

 

T2DM = yes

0.9 (− 0.7 to 2.6)

16 (− 13 to 47)

0.261

GC = yes

1.8 (0.2 to 3.4)

32 (4 to 61)

0.029

T2DM·GC = yes

1.3 (− 1.0 to 3.6)

23 (− 18 to 65)

0.259

  1. Bold values denote statistical significance at the P ≤ 0.05 level. Each headline for the schemes above  specifies how to interpret the coefficients of each scheme which differs among outcomes due to different statistical approaches