Table 2 Clinical outcomes for the intervention (dexmedetomidine) and control (propofol) groups
From: Dexmedetomidine versus propofol sedation in flexible bronchoscopy: a randomized controlled trial
Dexmedetomidine N = 30 | Propofol N = 33 | P value | |
|---|---|---|---|
Number of desaturation events | 1 (0–1) | 1 (0–2) | 0.29 |
Total desaturation time | 1 (0–2) | 1 (0–3) | 0.48 |
Number of patients with any desaturation events (%) | 16 (53) | 21(63) | 0.4 |
PcCO2 rise during procedure, mm/Hg | 18.45 (14.70–22.97) | 20.65 (15.37–30.07) | 0.46 |
Time period of PcCO2 > 50 mm/Hg in minutes | 17.5 (14.12–27.12) | 19.5 (7.75–29.75) | 0.94 |
Maximal level of PcCO2 during procedure mm/Hg | 56.45 (48.85–61.42) | 55.20 (52.82–68.37) | 0.53 |
RASS | − 2 [(− 3) to (− 2)] | − 3 [(− 3) to (− 2)] | 0.01 |
Procedure time | 20 (8–35) | 21 (15–27.5) | 0.7 |
Number of Propofol boluses needed | 2.5 (2–5) | 2 (1.0–2.5 | 0.016 |
Total bolus dose | 90 (50–109) | 58 (42–106.5) | 0.18 |
Patient satisfaction # | 5 (4.5–5) | 5 (5–5) | 0.10 |
Bronchoscopist satisfaction # | 4.5 (4–5) | 5 (5–5) | 0.012 |
Adverse events (%) | |||
Hypotension during procedure | 10 (33.3) | 4 (12.1) | 0.04 |
Bradycardia | 2 (6.7) | 0 | 0.22 |
Cough | 2 (6.7) | 0 | 0.22 |
Post-procedural Hypotension | 5 (16.7) | 3 (9.1) | 0.3 |
Delayed recovery from sedation | 3 (10) | 0 | 0.10 |
Total* | 22 | 7 | 0.009 |