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Table 1 Screening of the common etiology of FUO

From: Diffuse large B-cell lymphoma presenting as reversible intrapulmonary arteriovenous shunts with hypoxia, fever and progressive jaundice: a case report and literature review

Causes of FUO

Inspection item

Infectious diseases

Blood culture, blood mNGS, respiratory pathogens, PPD, brucella agglutination test, widals reaction, CMV/EBV-DNA, the antibody of toxoplasma, rubella virus, herpes simplex virus, hantaan virus, the pathogenic screening of CSF and BM

Malignancy disorders

Tumor marker, superficial lymph node ultrasound, chest CT, abdomen and pelvis CT, PET-CT, BM biopsy

Rheumatologic inflammatory disorders

ANA, anti-dsDNA, anti-ENA, ANCA, anti-GBM, myositis antibodies, vascular ultrasound

  1. mNGS, metagenomic next-generation sequencing; PPD, purified protein derivative; CMV, cytomegalovirus; EBV, Epstein-Barr virus; CSF, cerebrospinal fluid; BM, bone marrow; ANA, antinuclear antibody; ANCA, anti-neutrophil cytoplasmic antibody; anti-dsDNA, anti-double stranded deoxyribonucleic acid antibody; anti-ENA, anti-extractable nuclear antigen antibody; anti-GBM, anti-glomerular basement membrane