Characteristics | No. (%) | Conditional logistic regression | P for trend | ||||
---|---|---|---|---|---|---|---|
Case period | Control period | Crude OR (95% CI) | P value | Adjusted ORa (95% CI) | P value | ||
No use of antipsychotics | 17,900 (96.73) | 18,008 (97.31) | Ref | Â | Ref | Â | Â |
Any use of antipsychotics | 606 (3.3) | 498 (2.7) | 1.49 (1.26–1.77) | < 0.001 | 1.28 (1.06–1.57) | 0.011 |  |
Antipsychotics classb | Â | Â | Â | Â | Â | Â | Â |
 Typical only | 260 (1.40) | 186 (1.01) | 1.62 (1.29–2.03) | < 0.001 | 1.37 (1.07–1.76) | 0.012 |  |
 Atypical only | 326 (1.76) | 298 (1.61) | 1.32 (1.01–1.71) | 0.039 | 1.15 (0.86–1.54) | 0.344 |  |
 Both | 20 (0.11) | 14 (0.08) | 1.87 (0.81–4.30) | 0.142 | 1.60 (0.66–3.92) | 0.300 |  |
Dose | Â | Â | Â | Â | Â | Â | Â |
 Low (≤ 0.25 DDD) | 535 (2.89) | 441 (2.38) | 1.48 (1.25–1.76) | < 0.001 | 1.27 (1.05–1.54) | 0.016 | 0.005 |
 Medium to high (> 0.25 DDD) | 71 (0.38) | 57 (0.31) | 1.81 (1.17–2.78) | 0.007 | 1.65 (1.03–2.62) | 0.036 |  |
Dose (typical only) | Â | Â | Â | Â | Â | Â | Â |
 Low (≤ 0.25 DDD) | 249 (1.35) | 181 (0.98) | 1.60 (1.27–2.01) | < 0.001 | 1.37 (1.06–1.76) | 0.015 | 0.004 |
 Medium to high (> 0.25 DDD) | 11 (0.06) | 5 (0.03) | 4.30 (1.15–16.15) | 0.031 | 5.74 (1.33–24.67) | 0.019 |  |
Dose (atypical only) | Â | Â | Â | Â | Â | Â | Â |
 Low (≤ 0.25 DDD) | 271 (1.46) | 252 (1.36) | 1.30 (0.99–1.70) | 0.057 | 1.12 (0.83–1.52) | 0.451 | 0.282 |
 Medium to high (> 0.25 DDD) | 55 (0.30) | 46 (0.25) | 1.51 (0.92–2.47) | 0.107 | 1.33 (0.78–2.27) | 0.301 |  |