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Table 4 Comparison of 6-min walk test, arterial blood gases, pulmonary function tests and laboratory parameters between patients with mMRC < 2 and patients with mMRC ≥ 2

From: Association between obesity-related dyspnea in daily living, lung function and body composition analyzed by DXA: a prospective study of 130 patients

 

mMRC < 2 (n = 90)

mMRC ≥ 2 (n = 40)

p

6-min walk test (n = 119)

 6-min walk test distance (m)

457 (± 73)

395 (± 103)

0.0006**

 6-min walk test distance (% pred)

88 (± 15)

83 (± 19)

0.1517

 SpO2 at rest (%)

98 (± 1)

96 (± 6)

0.073

 SpO2 after 6MWT (%)

94 (± 3)

94 (± 3)

0.577

 Borg at rest (/10)

0.2 (± 0.4)

0.4 (± 0.9)

0.422

 Borg after 6MWT (/10)

3.3 (± 2.1)

4.7 (± 2.7)

0.014*

 Borg ≥  > 3 after 6MWT (/10)

32 (39%)

23 (64%)

0.01*

Arterial blood gases (n = 124)

 pH

7.42 (± 0.02)

7.41 (± 0.03)

0.312

 PaO2 (mmHg)

93 (± 13)

94 (± 17)

0.663

 PaCO2 (mmHg)

37 (± 3)

37 (± 4)

0.770

 HCO3− (mmol.L−1)

23 (± 2)

23 (± 2)

0.465

Pulmonary function tests

 Spirometry (n = 130)

   

  VC (mL)

3766 (± 847)

3362 (± 799)

0.005*

  VC (% pred)

106 (± 15)

95 (± 14)

0.0007**

  FVC (mL)

3729 (± 843)

3324 (± 812)

0.006*

  FVC (% pred)

105 (± 15)

95 (± 13)

0.002*

  FEV1 (mL)

3032 (± 657)

2646 (± 597)

0.0008**

  FEV1 (% pred)

100 (± 15)

90 (± 15)

0.0004**

  FEV1/FVC (% pred)

82 (± 6)

80 (± 7)

0.362

  ERV (mL)

627 (± 404)

464 (± 353)

0.024*

  ERV (% pred)

54 (± 27)

42 (± 28)

0.014*

Plethysmography (n = 110)

 RV (mL)

2069 (± 668)

1832 (± 710)

0.336

 RV (% pred)

122 (± 33)

110 (± 36)

0.197

 FRC (mL)

2719 (± 641)

2841 (± 739)

0.127

 FRC (% pred)

97 (± 20)

88 (± 22)

0.0504*

 TLC (mL)

5760 (± 1023)

5225 (± 1133)

0.033*

 TLC (% pred)

109 (± 16)

99 (± 16)

0.0036*

 DLCO (% pred)

90 (± 15)

85 (± 20)

0.166

Inspiratory muscle strength (n = 127)

 MIP (cmH2O)

63 (± 29)

56 (± 21)

0.358

 MIP (% pred)

73 (± 33)

64 (± 25)

0.189

Expiratory muscle strength (n = 127)

 MEP (cmH2O)

73 (± 37)

74 (± 36)

0.888

 MEP (% pred)

67 (± 30)

66 (± 30)

0.907

Laboratory parameters (n = 103)

 Hemoglobin (g/L)

135 (± 13)

132 (± 14)

0.245

 CRP (mg/L)

8.5 (± 7.8)

10.7 (± 9.7)

0.193

 NT-pro-BNP > 50 (pg/mL)

15 (22%)

8 (29%)

0.601

  1. Data are expressed as mean (± SD) or number (%). *p < 0.05; **p < 0.001
  2. p is in bold when it is < 0.05
  3. mMRC: modified Medical Research Council; 6MWT: six-minute walk test; SpO2: Pulse Oxygen Saturation; PaO2: Partial arterial pressure of oxygen, PaCO2: Partial arterial pressure of carbon dioxide; HCO3-: bicarbonate anion; VC: Vital capacity; FVC: Forced vital capacity; FEV1: Forced expiratory volume in one second; ERV: Expiratory reserve volume; RV: Residual volume; FRC: Functional residual capacity; TLC: Total lung capacity; DLCO: Diffusing capacity of the lung for carbon monoxide; MIP: Maximal inspiratory pressure; MEP: Maximal expiratory pressure; CRP: C-reactive protein; NT-pro-BNP: N-terminal prohormone of brain natriuretic peptide
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BMC Pulmonary Medicine

ISSN: 1471-2466

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