Table 1 Sample characteristics stratified by clusters
Total | Cluster #1 | Cluster #2 | P-value | |
|---|---|---|---|---|
Subjects, nr | 125 | 78 | 47 | |
Age, years | 11.4 (2.8) | 11.1 (3) | 11.8 (2.3) | 0.156 |
Sex, female | 61 (48.8) | 36 (46.2) | 25 (53.2) | 0.466 |
BMI Z score | − 0.57 (0.88) | − 0.68 (0.78) | − 0.37 (1.00) | 0.073 |
Pancreatic insufficiency | 74 (59.2) | 74 (94.9) | – | < 0.001 |
CFRD | 1 (0.8) | 1 (1.3) | – | 1.000 |
CFTR genotype | < 0.001 | |||
F508del/other | 50 (40.0) | 32 (41.0) | 18 (38.3) | |
F508del/F508del | 31 (24.8) | 30 (38.5) | 1 (2.1) | |
Other/other | 44 (35.2) | 16 (20.5) | 28 (59.6) | |
Pseudomonas aeruginosa, free | 76 (65) | 41 (52.6) | 35 (85.4) | < 0.001 |
FEV1% predicted | 100.4 (17.4) | 95.3 (18.0) | 109.0 (12.4) | < 0.001 |
FEV1 Z score | 0.05 (1.48) | − 0.38 (1.52) | 0.79 (1.08) | < 0.001 |
FVC % predicted | 107.4 (14.7) | 104.4 (16.0) | 112.4 (10.7) | 0.002 |
FVC Z score | 0.61 (1.23) | 0.35 (1.34) | 1.03 (0.90) | 0.001 |
LCI | 10.07 (2.98) | 11.33 (2.91) | 7.97 (1.57) | < 0.001 |
LCI Z score, median (IQR) | 5.22 (7.89) | 8.32 (8.44) | 0.98 (2.98) | < 0.001 |
Sacin*VT | 0.138 (0.109) | 0.161 (0.116) | 0.1 (0.084) | 0.001 |
Scond*VT | 0.066 (0.030) | 0.078 (0.024) | 0.045 (0.028) | < 0.001 |
Pulmonary exacerbationsa, median (IQR) | 2 (0–3) | 3 (1–4) | 0 (0–1) | < 0.001 |
Hospitalizationa | < 0.001 | |||
1 | 15 (12.0) | 15 (19.2) | – | |
⋝2 | 4 (3.2) | 4 (5.1) | – | |