Table 2 Drugs per patient consumption and unit costs, by FC. Sources: Botplus (2021) [80], AEMPS (2021) [71], Roman (2012) [72] and others [42, 43, 46, 47, 49,50,51,52,53,54,55,56,57, 60, 63, 105]
From: The economic burden of pulmonary arterial hypertension in Spain
Drug | Admins. route | Posology | Unit consumption | Pack cost | Presentation | Unit cost* | Total cost excl. adm. (patient/year) | Admin.cost (patient/year) | Total cost (patient/year) | Distribution of drug’s use | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FC I-II (%) | FC III (%) | FC IV (%) | Total (%) | ||||||||||
Sildenafil | O | 20 mg, 3×/day | 60 mg/day | €306.81 | 90 tabl | €0.17 | €3,732.86 | €0 | €3,732.86 | 9.6 | 8.2 | 11.1 | 9.1 |
Tadalafil | O | 40 mg, 1×/day | 40 mg/day | €324.48 | 56 tabl | €0.29 | €4,229.83 | €0 | €4,229.83 | 29.4 | 30.0 | 22.2 | 29.6 |
Riociguat | O | 1–2,5 mg, 3×/day | 3 tablets/day | €1,257.98 | 42 tabl | €29.95 | €32,797.44 | €0 | €32,797.44 | 0.0 | 2.7 | 0.0 | 1.2 |
Bosentan | O | 125 mg, 2×/day | 250 mg/day | €124.80 | 56 tabl | €0.02 | €1,626.86 | €0 | €1,626.86 | 14.7 | 6.4 | 0.0 | 10.7 |
Ambrisentan | O | 5-10 mg, 1×/day | 1 tablet/day | €859.04 | 30 tabl | €28.63 | €10,451.65 | €0 | €10,451.65 | 15.4 | 9.1 | 11.1 | 12.6 |
Macitentan | O | 10 mg, 1×/day | 10 mg/day | €2,446.08 | 30 tabl | €8.15 | €29,760.64 | €0 | €29,760.64 | 21.3 | 26.4 | 22.2 | 23.7 |
Selexipag (prevalents) | O | 200–1,600 mcg, 2×/day | 2 tablets/day | €3,717.17 | 60 tabl | €61.95 | €45,225.54 | €0 € | €45,225.54 | 2.9 | 8.2 | 0.0 | 5.1 |
Selexipag (incidents) | 2,6 tablets/day | €59,102.97 | €59,102.97 | ||||||||||
Iloprost | Inh | 5 mcg, 6–9×/day | 37,5 mcg/day | €414.69 | 30 blisters | €1.38 | €18,920.38 | €65.00 | €18,985.38 | 2.2 | 0.9 | 0.0 | 1.6 |
Treprostinil | IV | (1,5 vials 5 mg/ml) 1×/month | 7,5 mg/ml/month | €5,094.34 | 1 vial | €1,018.87 | €91,698.05 | €195.00 | €91,893.05 | 2.2 | 0.9 | 0.0 | 1.2 |
Epoprostenol | IV | 0,5 mg (9 vials 0,5 mg) 1×/48 h | 4,5 mg/48 h | €62.99 | 1 vial | €125.99 | €103,465.67 | €4,403.54 | €107,869.21 | 2.2 | 7.3 | 33.3 | 5.1 |