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Table 1 Baseline data of cases suspected of having a local pulmonary infection

From: Diagnostic performance of the metagenomic next-generation sequencing in lung biopsy tissues in patients suspected of having a local pulmonary infection

Characteristics

Pulmonary infectious disease with a definite pathogen (N = 49)

Pulmonary infectious disease with suspicion of infection with no identified pathogen (N = 27)

Non-infectious pulmonary diseases (N = 30)

Gender, N (%)

 Male

36 (73.5)

20 (74.1)

20 (66.7)

 Female

13 (26.5)

7 (25.9)

10 (33.3)

Age (years)

60 (46,65)

61 (50,71)

61 (50,71)

Symptom, N (%)

 Cough

35 (71.4)

20 (74.1)

21 (70.0)

 Expectoration

25 (51.0)

17 (63.0)

13 (43.3)

 Hemoptysis

12 (24.5)

5 (18.5)

3 (10.0)

 Dyspnea

7 (14.3)

3 (11.1)

10 (33.3)

 Fever

14 (28.6)

9 (33.3)

6 (20.0)

 Chest pain

13 (26.5)

3 (11.1)

7 (23.3)

 Other symptoms

5 (10.2)

3 (11.1)

5 (16.7)

 Asymptomatic

5 (10.2)

2 (7.4)

3 (10.0)

Symptom duration before admission (days)

 ≤ 1 month, N (%)

27 (55.1)

16 (59.3)

17 (56.7)

 > 1 month, ≤ 3 months, N (%)

7 (14.3)

4 (14.8)

5 (16.7)

 > 3 months, ≤ 1 year, N (%)

10 (20.4)

4 (14.8)

4 (13.3)

 > 1 year, N (%)

5 (10.2)

3 (11.1)

4 (13.3)

Underlying disease, N (%)

 Hypertension

15 (30.6)

9 (33.3)

10 (33.3)

 Diabetes mellitus

8 (16.3)

7 (25.9)

7 (23.3)

 Malignant tumor

1 (2.0)

2 (7.4)

4 (13.3)

 Immunosuppressive status

7 (14.3)

3 (11.1)

4 (13.3)

 Other diseases

2 (4.1)

2 (7.4)

1 (3.3)

 No underlying disease, N (%)

29 (59.2)

15 (55.6)

15 (50.0)

Laboratory examination

 White blood cell count (× 109/L)

7.5 (5.7,12.0)

8.7 (6.1,12.7)

8.7 (6.4,10.6)

 Percentage of neutrophils (%)

67.7 (59.2,76.1)

69.8 (64.5,84.2)

68.9 (63.0,78.4)

 Percentage of lymphocytes (%)

22.1 (11.6,30.3)

20.3 (9.2,24.3)

16.7 (10.1,25.1)

Lobes of the lungs involved, N (%)

 Single lobe

20 (40.8)

9 (33.3)

5 (16.7)

 Multi lobes

29 (59.2)

18 (66.7)

25 (83.3)

Imaging features, N (%)

 Consolidation

16 (32.7)

9 (33.3)

11 (36.7)

 Nodule or mass

38 (77.6)

21 (77.8)

25 (83.3)

 Cavity

12 (24.5)

5 (18.5)

8 (26.7)

 Necrosis

14 (28.6)

5 (18.5)

4 (13.3)

 Interstitial lesion

2 (4.1)

0

2 (6.7)

 Pleural effusion

11 (22.4)

4 (14.8)

8 (26.7)

 Mediastinal lymph node enlargement

14 (28.6)

4 (14.8)

12 (40.0)