Diagnostic performance of the metagenomic next-generation sequencing in lung biopsy tissues in patients suspected of having a local pulmonary infection

Table 3 Comparison of diagnostic performance between mNGS and conventional examinations (CE) in identify the pathogen in suspected local pulmonary infection

In the diagnosis of suspected local pulmonary infections, the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of CE were 42.1%, 96.7%, 97.0% and 39.7%. Respectively, the sensitivity and specificity of mNGS were 53.9% and 56.7%, while the PPV and NPV were 75.9% and 32.7%. There was a poor agreement between CE and mNGS, and the value of kappa coefficient was 0.269 (95% CI: 0.077 to 0.422)

ISSN: 1471-2466