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Table 1 Patient characteristics of the retrospective review

From: Exploring red cell distribution width as a biomarker for treatment efficacy in home mechanical ventilation

 

CRF patients

(n = 79)

HMV patients

(n = 83)

healthy patients

(n = 29)

p-value

Demographic data

 Age (years)

53 (41–62)

55 (42–69)

53 (41–64)

p = 0.537

Sex

 Female

20 (25.3%)

22 (26.5%)

7 (24.1%)

p = 0.965

 Male

59 (74.7%)

61 (73.5%)

22 (75.8%)

 

Diagnosis/HMV indication

 COPD

8 (10.1%)

13 (15.7%)

 

p = 1.000

 RCDW

5 (6.3%)

4 (4.8%)

  

 OHS

26 (32.9%)

26 (31.3%)

  

 NMD

19 (24.1%)

20 (24.1%)

  

 ALS

14 (17.7%)

12 (14.5%)

  

 PD

2 (2.5%)

3 (3.6%)

  

 SCT

5 (6.3%)

5 (6.0%)

  

Interface

 Noninvasive

 

68 (81.9%)

  

 Invasive

 

15 (18.1%)

  

 HMV duration (months)

 

6 (4–27)

  

 O2 supplementation need

    

 No

45 (57.0%)

47 (56.6%)

 

p = 1.000

 Yes

34 (43.0%)

36 (43.4%)

  

Laboratory parameters

 RDW (%)

14.5 (13.2–15.6)

13.9 (13.2–15.3)

12.8 (12.3–13.6)

p < 0.001

 HGB (g/L)

130 (107–149)

137 (121–148)

141 (133–151)

p = 0.051

 HCT (L/L)

0.39 (0.34–0.46)

0.4 (0.37–0.45)

0.41 (0.39–0.44)

p = 0.503

 RBC (Tera/L)

4.42 (3.82–5.17)

4.67 (4.18–5.02)

4.7 (4.41–4.96)

p = 0.555

 MCV (fL)

87.2 (85–89.5)

87.8 (85.5–90.8)

87.9 (85.6–89.8)

p = 0.653

 MCH (pg)

29 (27.4–29.8)

29.2 (28.4–30.5)

29.6 (28.9–30.7)

p = 0.011

 MCHC (g/L)

327 (315–337)

333 (325–341)

342 (334–347)

p < 0.001

 WBC (Giga/L)

8.33 (6.77–10.86)

8.71 (7.12–10.77)

6.33 (5.7–7.65)

p < 0.001

 PLT (Giga/L)

261 (215–346)

248 (218–306)

255 (231–282)

p = 0.317

 MPV (fL)

10.35 (9.1–11.1)

10.8 (9.9–11.5)

10.3 (10–10.8)

p = 0.009

 CRP (mg/L)

7.2 (2.5–19.1)

6.35 (2.7–11.8)

2.7 (1.6–10.6)

p = 0.065

  1. Significant differences are marked with bold font
  2. Data is presented as n (%) and median (IQR). Comparison between the parameters of the three groups in the retrospective analysis was performed using the Kruskal–Wallis ANOVA by Ranks test for continuous, and the Pearson Chi-square test for categorical variables. Mann–Whitney U test was used when comparing two groups (such as in the case of O2 supplementation need and diagnosis differences). Significant differences are marked with bold font
  3. ALS amyotrophic lateral sclerosis, COPD chronic obstructive pulmonary disease, CRF chronic respiratory failure, CRP C-reactive protein, HCT haematocrit, HGB haemoglobin, HMW home mechanical ventilation, MCH mean cell haemoglobin, MCHC mean cell haemoglobin concentration, MCV mean cell volume, MPV mean platelet volume, NMD neuromuscular disease, OHS obesity hypoventilation syndrome, PD pulmonary disease, PLT platelet, RBC red blood cell, RCDW restrictive chest wall disease, RDW red cell distribution width, SCT spinal cord transection, WBC white blood cell