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Table 1 Laboratory parameters after hypertonic bicarbonate aerosol and cigarette smoke exposure compared to sodium chloride treatment

From: Safety of chronic hypertonic bicarbonate inhalation in a cigarette smoke-induced airway irritation guinea pig model

Parameter

NaCl

NaHCO3

NaCl + CSE

NaHCO3 + CSE

Arterial pH

7.17

7.35 ± 0.22

7.23

7.16 ± 0.07

standard HCO3 (mmol/l)

17.1

26.9 ± 5.85

19.1

18.1 ± 1.52

PaCO2 (mmHg)

64.3

59.5 ± 10.45

59

72.83 ± 4.61

Glucose (mmol/l)

6.08 ± 0.31

6.87 ± 0.26

7.21 ± 0.54

7.35 ± 0.29

Triglyceride (mmol/l)

1.32 ± 0.21

1.27 ± 0.29

1.38 ± 0.08

1.40 ± 0.44

Total bilirubin (mmol/l)

1.10 ± 0.11

1.00 ± 0.32

0.78 ± 0.05

0.83 ± 0.19

Direct bilirubin (mmol/l)

0.33 ± 0.05

0.40 ± 0.17

0.23 ± 0.05

0.25 ± 0.06

ALT (IU/l)

71.68 ± 5.89

77.35 ± 4.63

66.60 ± 7.58

65.23 ± 6.71

AST (IU/l)

103.33 ± 21.08

85.25 ± 6.52

127.55 ± 16.81

118.55 ± 22.00

GGT (IU/I)

8.85 ± 2.28

6.48 ± 0.59

7.55 ± 0.61

7.70 ± 0.33

ALP (IU/l)

73.25 ± 4.11

71.75 ± 7.44

68.50 ± 7.40

68.50 ± 7.40

LDH (IU/l)

140.75 ± 21.55

128.25 ± 38.94

169.25 ± 21.78

142.50 ± 13.58

Cholesterol (mmol/l)

0.78 ± 0.17

0.82 ± 0.09

0.80 ± 0.05

0.93 ± 0.13

Amylase (IU/l)

2304.5 ± 126.70

2114.50 ± 132.35

2270.25 ± 128.72

2497.75 ± 136.27

Lipase (IU/I)

31.50 ± 14.65

18.50 ± 5.20

15.50 ± 0.65

25.25 ± 8.50

Total Protein (g/l)

55.23 ± 0.54

51.90 ± 0.99

52.55 ± 2.41

56.78 ± 1.98

Urea (mmol/l)

10.73 ± 0.46

10.18 ± 0.89

10.00 ± 1.25

11.28 ± 0.99

K+ (mmol/l)

9.19 ± 1.15

8.38 ± 1.37

8.47 ± 0.37

7.48 ± 0.77

Cl (mmol/l)

94.00 ± 0.41

92.25 ± 1.93

96.00 ± 0.58

94.25 ± 0.85

Ca2+ (mmol/l)

2.89 ± 0.05

2.66 ± 0.07

2.77 ± 0.06

3.00 ± 0.04

Mg2+ (mmol/l)

1.26 ± 0.07

0.98 ± 0.06

1.09 ± 0.04

1.14 ± 0.06

P (mmol/l)

2.39 ± 0.43

1.97 ± 0.28

2.12 ± 0.08

2.19 ± 0.18

Fe (mmol/l)

36.40 ± 2.91

38.10 ± 2.78

41.10 ± 3.82

46.28 ± 5.95

  1. Data represent mean ± SEM of 4 animals/group. PaCO2: ALT: alanine transaminase, AST: aspartate transaminase, GGT: gamma-glutamyl-transpeptidase, ALP: alkaline phosphatase, LDH: lactate dehydrogenase, K + : potassium, Cl-: chloride, Ca2 + : calcium, Mg2 + : magnesium, P: phosphorus, Fe: iron