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Table 2 Penalized logistic regression model to predict amiodarone pulmonary toxicity

From: A multicenter retrospective cohort study on predicting the risk for amiodarone pulmonary toxicity

Variables

Univariate analysis

Odds ratios (95% CI)

p value

Multivariable analysis

Odds ratios (95% CI)

p value

Gender, male

0.887 (0.436–1.805)

0.741

  

Age, years*

1.032 (1.002–1.063)

0.039

1.047 (1.010–1.085)

0.013

Current or ex-smoker

1.977 (0.997–3.921)

0.051

  

Underlying lung disease*

3.779 (1.778–8.033)

0.001

2.703 (1.053–6.935)

0.039

Ventricular arrhythmia*

2.564 (1.299–5.063)

0.007

2.511 (1.146–5.501)

0.021

eGFR

0.996 (0.985–1.008)

0507

  

Duration of amiodarone use

1.010 (1.004–1.016)

0.002

  

Daily amiodarone dose

1.001 (0.997–1.005)

0.662

  

Amiodarone-related thyroid dysfunction

1.481 (0.638–3.436)

0.360

  

Cumulative dose of amiodarone*

4.556 (1.781–11.653)

0.002

4.762 (1.310-17.309)

0.018

  1. Bold indicates factors that are statistically significant
  2. *Factors that are statistically significant after adjustment for age, gender and smoking history