From: A multicenter retrospective cohort study on predicting the risk for amiodarone pulmonary toxicity
Variables | Univariate analysis Odds ratios (95% CI) | p value | Multivariable analysis Odds ratios (95% CI) | p value |
---|---|---|---|---|
Gender, male | 0.887 (0.436–1.805) | 0.741 | ||
Age, years* | 1.032 (1.002–1.063) | 0.039 | 1.047 (1.010–1.085) | 0.013 |
Current or ex-smoker | 1.977 (0.997–3.921) | 0.051 | ||
Underlying lung disease* | 3.779 (1.778–8.033) | 0.001 | 2.703 (1.053–6.935) | 0.039 |
Ventricular arrhythmia* | 2.564 (1.299–5.063) | 0.007 | 2.511 (1.146–5.501) | 0.021 |
eGFR | 0.996 (0.985–1.008) | 0507 | ||
Duration of amiodarone use | 1.010 (1.004–1.016) | 0.002 | ||
Daily amiodarone dose | 1.001 (0.997–1.005) | 0.662 | ||
Amiodarone-related thyroid dysfunction | 1.481 (0.638–3.436) | 0.360 | ||
Cumulative dose of amiodarone* | 4.556 (1.781–11.653) | 0.002 | 4.762 (1.310-17.309) | 0.018 |