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Table 3 Association between patient diagnosis groups and self-reported disease in the family

From: Clustering of lung diseases in the family of interstitial lung disease patients

Patient diagnosis group

Self-reported disease in family

Unadjusted

Adjusted for age

Adjusted for sex and age

 

Significantly higher frequency of disease in the family

IPF

any ILD

1.9 (1.2–3.1)

2.6 (1.5–4.3)

2.6 (1.6–4.4)

Sarcoidosis

sarcoidosis

4.3 (2.6–7.1)

3.3 (1.9–5.8)

3.3 (1.9–5.8)

IPF

pulmonary fibrosis

8.1 (4.5–14.5)

7.9 (4.1–15.1)

9.2 (4.7–17.9)

uPF

pulmonary fibrosis

4.5 (2.4–8.4)

3.9 (1.9–7.9)

4.1 (2.0–8.2)

HP

COPD

2.1 (1.2–3.8)

2.4 (1.3–4.2)

2.3 (1.3–4.2)

IPF

lung cancer

1.8 (1.2–2.8)

2.2 (1.4–3.4)

2.3 (1.4–3.5)

 

Significantly lower frequency of disease in the family

Non-IPF IIP

any ILD

0.1 (0.0–0.7)

0.1 (0.0–0.8)

0.1 (0.0–0.8)

Sarcoidosis

pulmonary fibrosis

0.1 (0.1–0.2)

0.1 (0.0–0.2)

0.1 (0.0–0.2)

Sarcoidosis

non-ILD lung disease

0.7 (0.6–0.9)

0.6 (0.5–0.8)

0.6 (0.5–0.8)

Sarcoidosis

lung disease, n.s

0.6 (0.5–0.9)

0.6 (0.4–0.9)

0.6 (0.4–0.9)

  1. For significant results (p < 0.05 Chi squared or Fisher’s exact when appropriate) the odds ratio and 95% confidence interval from logistic regression analysis (with and without adjustment for sex or age) are presented. HP = hypersensitivity pneumonitis; IPF = idiopathic pulmonary fibrosis; uPF = unclassifiable pulmonary fibrosis; non-IPF IIP = idiopathic interstitial pneumonia other than IPF; aidILD = autoimmune disease interstitial lung disease; oILD = other interstitial lung disease; n.s. = not specified