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Table 3 Association between patient diagnosis groups and self-reported disease in the family

From: Clustering of lung diseases in the family of interstitial lung disease patients

Patient diagnosis group Self-reported disease in family Unadjusted Adjusted for age Adjusted for sex and age
  Significantly higher frequency of disease in the family
IPF any ILD 1.9 (1.2–3.1) 2.6 (1.5–4.3) 2.6 (1.6–4.4)
Sarcoidosis sarcoidosis 4.3 (2.6–7.1) 3.3 (1.9–5.8) 3.3 (1.9–5.8)
IPF pulmonary fibrosis 8.1 (4.5–14.5) 7.9 (4.1–15.1) 9.2 (4.7–17.9)
uPF pulmonary fibrosis 4.5 (2.4–8.4) 3.9 (1.9–7.9) 4.1 (2.0–8.2)
HP COPD 2.1 (1.2–3.8) 2.4 (1.3–4.2) 2.3 (1.3–4.2)
IPF lung cancer 1.8 (1.2–2.8) 2.2 (1.4–3.4) 2.3 (1.4–3.5)
  Significantly lower frequency of disease in the family
Non-IPF IIP any ILD 0.1 (0.0–0.7) 0.1 (0.0–0.8) 0.1 (0.0–0.8)
Sarcoidosis pulmonary fibrosis 0.1 (0.1–0.2) 0.1 (0.0–0.2) 0.1 (0.0–0.2)
Sarcoidosis non-ILD lung disease 0.7 (0.6–0.9) 0.6 (0.5–0.8) 0.6 (0.5–0.8)
Sarcoidosis lung disease, n.s 0.6 (0.5–0.9) 0.6 (0.4–0.9) 0.6 (0.4–0.9)
  1. For significant results (p < 0.05 Chi squared or Fisher’s exact when appropriate) the odds ratio and 95% confidence interval from logistic regression analysis (with and without adjustment for sex or age) are presented. HP = hypersensitivity pneumonitis; IPF = idiopathic pulmonary fibrosis; uPF = unclassifiable pulmonary fibrosis; non-IPF IIP = idiopathic interstitial pneumonia other than IPF; aidILD = autoimmune disease interstitial lung disease; oILD = other interstitial lung disease; n.s. = not specified