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Table 5 Comparison of reported lung disease in the family between patients with sporadic and familial sarcoidosis or pulmonary fibrosis

From: Clustering of lung diseases in the family of interstitial lung disease patients

  Sarcoidosis pulmonary fibrosis
Sporadic Familial Sporadic Familial
n = 554 n = 90 n = 175 n = 37
Disease in relatives, n (%):     
Sarcoidosis 0 (0) 90 (100) 7 (4) 1 (3)
Pulmonary fibrosis 6 (1) 1 (1) 0 (0) 37 (100)
Remaining ILD 8 (1) 3 (3) 3 (2) 2 (5)
Non-ILD lung disease 337 (61) 58 (64) 118 (67) 26 (70)
Asthma 136 (25) 24 (27) 21 (12) 5 (14)
Bronchitis 84 (15) 17 (19) 15 (9) 1 (3)
COPD 55 (10) 10 (11) 16 (9) 4 (11)
Emphysema 38 (7) 7 (8) 13 (7) 10 (27)*
P 0.002
OR 4.6 (1.8–11.6)
Pneumonia 33 (6) 2 (2) 19 (11) 2 (5)
Tuberculosis 49 (9) 7 (8) 21 (12) 5 (14)
Lung cancer 127 (23) 26 (29) 46 (26) 17 (46)*
P 0.017
OR 2.4 (1.2–4.9)
Lung disease n.s 70 (13) 15 (17) 37 (21) 8 (22)
  1. *Significant difference (Chi squared or Fisher’s exact, p < 0.05) between sporadic and familial pulmonary fibrosis. The odds ratio (OR) with 95% confidence interval between brackets are presented in case of significant results. n.s. = not specified