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Table 1 Characteristics of patients with CTEPH and control participants

From: Altered gut microbiota and its association with inflammation in patients with chronic thromboembolic pulmonary hypertension: a single-center observational study in Japan

Factor

Group

Control

CTEPH

P-value

  

(n = 22)

(n = 11)

 

Age

Years

65.5 ± 11.6

65.5 ± 12.2

0.94

Sex

Female/male

14-Aug

07-Apr

1

BMI

 

23.0 ± 4.3

23.7 ± 6.1

0.89

History of acute PE

 

No data

9

 

History of DVT

 

No data

5

 

Disease duration from onset to diagnosis

(months)

No data

52.5 ± 56.9

 

NYHA classification

1/2/3/4

No data

0/7/4/0

 

Location of thrombus*

 

No data

Main PA: 6

 
   

Lobar PA: 4

 
   

Segmental PA: 1

 

Hemodynamics

    

Mean PAP

(mmHg)

No data

44.1 ± 9.1

 

PAR

(dyne sec cm−5)

No data

748 ± 254

 

CI

(L/min/m2)

No data

2.43 ± 0.51

 

Medication

    

Proton pump inhibitors

 

2

6

 < 0.01

Antibiotics

 

0

0

1

Laxatives

 

0

0

1

Antiflatulents

 

0

1

0.3

sGC stimulators

 

0

8

 < 0.01

  1. *The most proximal site where chronic thromboembolism started within the pulmonary arteries assessed using enhanced computed tomography scan and pulmonary angiography. BMI, body mass index; PE: pulmonary embolism; DVT: deep vein thrombosis; CI, cardiac index; NYHA: New York Heart Association; PA, pulmonary artery; sGC, soluble guanylate cyclase; CTEPH, chronic thromboembolic pulmonary hypertension; PAP, pulmonary arterial pressure; PAR, pulmonary arterial resistance