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Fig. 3 | BMC Pulmonary Medicine

Fig. 3

From: Dapagliflozin, sildenafil and their combination in monocrotaline-induced pulmonary arterial hypertension

Fig. 3

Treatment with dapagliflozin attenuated pulmonary vascular remodelling in MCT-injected rats (n = 9–10). A Images of H&E staining for the morphology of pulmonary arteries. B Representative images of immunohistochemistry for α-SMA in pulmonary arteries. C Quantification of pulmonary artery medial thickness (PAMT). D Quantification of α-SMA in pulmonary arteries. Values are means ± SD. Comparisons were made by the Student’s t-test. Dapa, dapagliflozin; MCT, Monocrotaline; Veh, vehicle; Silde, sildenafil. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 versus MCT rats treated with vehicle

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