Fig. 4

Treatment with dapagliflozin attenuated pulmonary vascular remodelling in MCT-injected rats (n = 9–10). A Representative images of immunohistochemistry for CD68 in pulmonary arteries. B Representative images of immunohistochemistry for Ki67 in pulmonary arteries. C Quantification of CD68-positive cells per pulmonary vessel. D Quantification of Ki67-positive cells per pulmonary vessel. Values are means ± SD. Comparisons were made by the Student’s t-test. Dapa, dapagliflozin; MCT, Monocrotaline; Veh, vehicle; Silde, sildenafil. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 versus MCT rats treated with vehicle