Integrated analysis of mRNA and long noncoding RNA profiles in peripheral blood mononuclear cells of patients with bronchial asthma

Table 2 Core mRNAs selected using the gene–gene functional interaction network

Gene symbol	Style	Betweenness centrality	Degree
NFKB1	Up	0.052151	35
PRKACB	Down	0	32
PIK3CA	Down	0.033763	29
PLCB1	Down	0.04064	24
PLCG1	Up	0.02381	23
GNAI3	Down	0.0408	21
JUN	Down	0.030527	20
TP53	Up	0.040001	19
KRAS	Down	0.026864	18
NRAS	Down	0.026311	18
JAK2	Down	0.011193	18
FOXO3	Down	0.024722	17
FOS	Down	0.019986	17
ENPP3	Down	0.014337	16
STAT1	Down	0.014575	12
IFNG	Down	0.013518	12
PLA2G4A	Down	0.006587	12
PLD1	Down	0.005553	12
CREB1	Down	0.006042	11
IL6	Down	0.00833	11

Betweenness centrality ≥ 0.005. Betweenness centrality is an indicator of a gene’s centrality in a network. It is equal to the number of shortest paths from all vertices to all others that pass through that gene. The degree of a gene was defined as the number of directly linked genes within a network

ISSN: 1471-2466