Table 6 Suggested procalcitonin (PCT) cut-offs to predict bacterial versus non-bacterial AECOPD
Author | Setting | Number of Exacerbations | Number of Exacerbations with Bacterial Cause | Cut-off / ng/mL | Sensitivity / % | Specificity / % | Positive Predictive Value / % | Negative Predictive Value / % |
|---|---|---|---|---|---|---|---|---|
Ergan [11] | ICU | 52 | 16 | 0.25 | 63 | 67 | 0.45 | 0.80 |
Nseir (all patients) [12] | ICU | 98 | 40 | 0.5 | 45 | 70.7 | 51 | 65 |
Nseir (Abx excluded) | Â | Â | Â | 0.5 | 53.5 | 87.5 | 83.3 | 61.7 |
Tanriverdi [13] | ICU | 77 | 28 | 0.40 | 61 | 67 | – | – |
|  |  |  |  | 1.03 | 43 | 83 | – | – |
|  |  |  |  | 0.10 | 75 | 40 | – | – |
Van de Geijn [37] | H | 45 | 22 | 0.03 | 91 | 36 | – | – |
Xiong [35] | H | 78 | 38 | 0.76 | 78.95 | 92.50 | 96.74 | 74.21 |