Table 7 Description of studies assessing the properties of Sputum IL-8 for identifying bacterial vs non-bacterial AECOPD
Author | Setting | Antibiotics or Steroids in the exclusion criteria (length of exclusion) | GOLD Stage of Cohort | Definition of Bacterial Cause of Exacerbation | Number of Exacerbations | Number of Exacerbations with Bacterial Cause | Mean IL-8 (SD) Bacterial Exacerbation | Mean IL-8 (SD) Non-bacterial Exacerbation |
|---|---|---|---|---|---|---|---|---|
Aaron [47] | OP | Steroids | – | Positive sputum culture of pathogen not cultured at baseline | 14 | 1 | – | – |
Bafadhel [39] | OP | Antibiotics & Steroids | I–IV | Positive sputum culture OR total aerobic count > 107 CFU | 158 | 84 | 8926 pg/mL | 3221 pg/mL |
Bathoorn [40] | OP | Steroids | – | High semi-quantitative growth density of PPM on sputum culture | 37 | 8 | 7.78 μg/mL | 1.74 μg/mL |
Dal Negro [16] | H | Antibiotics | II | Positive sputum culture > 106 CFU/mL | 124 | CB = 28 PA = 20 | CB = 16,599.6 pg/mL PA = 16,087.4 pg/mL | NI = 8201.8 pg/mL V = 9996.0 pg/mL |
Sethi [46] | OP | – | I–IV | Molecular typing of strains from sputum | 150 | 84 | – | – |
Vaitkus [23] | H | Antibiotics (1 month) & Steroids (1 month) | – | Positive sputum culture > 106 CFU/mL | 40 | 18 | 468 pg/mL | 410 pg/mL |
Wilkinson [43] | OP | Antibiotics | – | – | 39 | – | – | – |