R5 | R20 | R5-R20 | X5 | Fres | AX | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
≥ 0.39 | < 0.39 | ≥ 0.27 | < 0.27 | ≥ 0.10 | < 0.10 | ≦ − 0.13 | > − 0.13 | ≥ 17.7 | < 17.7 | ≥ 0.55 | < 0.55 | |
Number of participants | 11 | 54 | 8 | 57 | 21 | 44 | 26 | 39 | 38 | 27 | 36 | 29 |
Age | 74.6 (1.8) | 68.6 (1.1)* | 70.8 (3.4) | 69.5 (1.0) | 72.1 (2.0) | 68.5 (1.1) | 72.7 (1.4) | 67.6 (1.3) | 70.6 (1.4) | 68.3 (1.3) | 71.1 (1.5) | 67.9 (1.2) |
Sex; Male:Female | 6:5 | 47:7* | 5:3 | 48:9 | 15:6 | 38:6 | 20:6 | 33:6 | 29:9 | 24:3 | 27:9 | 26:3 |
Body mass index | 21.4 (1.0) | 22.7 (0.4) | 22.2 (1.4) | 22.5 (0.4) | 21.4 (0.7) | 22.9 (0.5) | 22.0 (0.6) | 22.7 (0.5) | 22.2 (0.5) | 22.8 (0.5) | 22.3 (0.6) | 22.7 (0.5) |
Smoking history (pack-years) | 51.4 (2.4) | 51.8 (2.2) | 49.4 (2.3) | 52.1 (2.0) | 52.6 (3.2) | 51.3 (2.3) | 52.7 (1.6) | 51.1 (2.9) | 51.7 (2.0) | 51.8 (3.5) | 52.3 (2.6) | 51.1 (2.7) |
Current: Former | 2:9 | 11:43 | 4:4 | 9:48 | 5:16 | 8:36 | 6:20 | 7:32 | 10:28 | 3:24 | 10:26 | 3:26 |
Laboratory values | ||||||||||||
Neutrophil in blood (count/µl) | 4253 (373) | 3735 (140) | 4445 (344) | 3735 (129) | 3984 (255) | 3746 (155) | 4043 (219) | 3676 (166) | 4036 (177) | 3522 (191) | 4038 (178) | 3555 (192) |
Eosinophil in blood (count/µl) | 185 (36) | 208 (17) | 231 (48) | 201 (18) | 176 (20) | 218 (21) | 212 (23) | 200 (21) | 215 (20) | 189 (25) | 221 (22) | 184 (22) |
Total IgE in serum (IU/ml) | 184 (91) | 458 (127) | 528 (410) | 396 (109) | 221 (106) | 503 (149) | 342 (153) | 458 (148) | 448 (166) | 361 (113) | 448 (175) | 367 (105) |
mMRC | 1.6 (0.2) | 1.2 (0.1) | 1.4 (0.2) | 1.3 (0.1) | 1.5 (0.1) | 1.2 (0.1)* | 1.5 (0.1) | 1.2 (0.1)* | 1.4 (0.1) | 1.1 (0.1)** | 1.4 (0.1) | 1.1 (0.1)* |
CAT | 8.5 (1,6) | 5.4 (0.6) | 5.9 (2.1) | 6.0 (0.6) | 7.4 (1.1) | 5.3 (0.7) | 7.5 (1.1) | 4.9 (0.6)* | 7.3 (0.9) | 4.1 (0.6)** | 6.6 (0.9) | 5.1 (0.8) |
FEV1 | ||||||||||||
Baseline (L) | 1.04 (0.07) | 1.79 (0.08)** | 1.22 (0.10) | 1.72 (0.08)* | 1.17 (0.06) | 1.89 (0.09)** | 1.28 (0.07) | 1.91 (0.09)** | 1.34 (0.07) | 2.11 (0.10)** | 1.34 (0.06) | 2.07 (0.11)** |
After 5 years (L) | 0.98 (0.08) | 1.69 (0.08)** | 1.04 (0.13) | 1.65 (0.08)** | 1.09 (0.05) | 1.80 (0.09)** | 1.16 (0.07) | 1.85 (0.09)** | 1.24 (0.07) | 2.04 (0.10)** | 1.22 (0.06) | 2.00 (0.11)** |
Annual change (ml/year) | − 12.7 (8.8) | − 19.0 (4.5) | − 36.8 (11.0) | − 15.3 (4.2) | − 17.1 (6.7) | − 18.3 (5.0) | − 24.2 (7.7) | − 13.8 (4.3) | − 20.2 (5.9) | − 14.8 (4.9) | − 22.1 (6.1) | − 12.8 (4.8)* |
%FEV1 | ||||||||||||
Baseline (%) | 50.1 (2.5) | 65.4 (2.2)** | 53.4 (3.9) | 64.1 (2.1) | 50.0 (2.7) | 68.9 (2.1)** | 54.0 (2.8) | 68.7 (2.3)** | 54.3 (2.0) | 74.7 (2.0)** | 54.6 (2.0) | 73.0 (2.6)** |
After 5 years (%) | 50.1 (2.7) | 65.8 (2.4)** | 48.1 (2.7) | 65.2 (2.3)** | 50.1 (2.9) | 69.3 (23)** | 52.2 (2.8) | 70.4 (2.5)** | 53.6 (2.2) | 76.6 (5.4)** | 53.5 (2.1) | 75.0 (2.8)** |
Annual change (%/year) | 0.001 (0.50) | 0.08 | − 1.05 (0.54) | 0.22 (0.18)* | 0.03 (0.29) | 0.08 (0.23) | − 0.35 (0.35) | 0.34 (0.18) | − 0.16 (0.32) | 0.38 (0.19) | − 0.20 (0.28) | 0.40 (0.19)* |
Comorbidity | ||||||||||||
Pneumonia n (+ : −) | 7:4 | 19:35 | 5:3 | 19:38 | 13:8 | 13:31* | 15:11 | 11:28* | 20:18 | 6:21* | 19:17 | 7:22* |
Asthma n (+ : −) | 7:4 | 17:37 | 6:2 | 18:3* | 11:10 | 13:31 | 14:12 | 10:29* | 19:19 | 5:22* | 20:16 | 4:25** |
Cancer n (+ : −) | 3:8 | 15:39 | 1:7 | 17:40 | 7:14 | 11:33 | 8:18 | 10:29 | 11:27 | 7:20 | 11:25 | 7:22 |
Cardio-vascular dis. n (+ : −) | 3:8 | 14:30 | 1:7 | 16:41 | 8:13 | 9:35 | 7:19 | 10:29 | 8:30 | 9:18 | 9:27 | 8:21 |