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Table 3 Comparison of annual change in FEV1 and comorbidity between patients with COPD classified by baseline impulse oscillometry system (IOS) parameter values

From: Association between annual change in FEV1 and comorbidities or impulse oscillometry in chronic obstructive pulmonary disease

 

R5

R20

R5-R20

X5

Fres

AX

 

 ≥ 0.39

 < 0.39

 ≥ 0.27

 < 0.27

 ≥ 0.10

 < 0.10

 − 0.13

 >  − 0.13

 ≥ 17.7

 < 17.7

 ≥ 0.55

 < 0.55

Number of participants

11

54

8

57

21

44

26

39

38

27

36

29

Age

74.6 (1.8)

68.6 (1.1)*

70.8 (3.4)

69.5 (1.0)

72.1 (2.0)

68.5 (1.1)

72.7 (1.4)

67.6 (1.3)

70.6 (1.4)

68.3 (1.3)

71.1 (1.5)

67.9 (1.2)

Sex; Male:Female

6:5

47:7*

5:3

48:9

15:6

38:6

20:6

33:6

29:9

24:3

27:9

26:3

Body mass index

21.4 (1.0)

22.7 (0.4)

22.2 (1.4)

22.5 (0.4)

21.4 (0.7)

22.9 (0.5)

22.0 (0.6)

22.7 (0.5)

22.2 (0.5)

22.8 (0.5)

22.3 (0.6)

22.7 (0.5)

Smoking history (pack-years)

51.4 (2.4)

51.8 (2.2)

49.4 (2.3)

52.1 (2.0)

52.6 (3.2)

51.3 (2.3)

52.7 (1.6)

51.1 (2.9)

51.7 (2.0)

51.8 (3.5)

52.3 (2.6)

51.1 (2.7)

Current: Former

2:9

11:43

4:4

9:48

5:16

8:36

6:20

7:32

10:28

3:24

10:26

3:26

Laboratory values

            

Neutrophil in blood (count/µl)

4253 (373)

3735 (140)

4445 (344)

3735 (129)

3984 (255)

3746 (155)

4043 (219)

3676 (166)

4036 (177)

3522 (191)

4038 (178)

3555 (192)

Eosinophil in blood (count/µl)

185 (36)

208 (17)

231 (48)

201 (18)

176 (20)

218 (21)

212 (23)

200 (21)

215 (20)

189 (25)

221 (22)

184 (22)

Total IgE in serum (IU/ml)

184 (91)

458 (127)

528 (410)

396 (109)

221 (106)

503 (149)

342 (153)

458 (148)

448 (166)

361 (113)

448 (175)

367 (105)

mMRC

1.6 (0.2)

1.2 (0.1)

1.4 (0.2)

1.3 (0.1)

1.5 (0.1)

1.2 (0.1)*

1.5 (0.1)

1.2 (0.1)*

1.4 (0.1)

1.1 (0.1)**

1.4 (0.1)

1.1 (0.1)*

CAT

8.5 (1,6)

5.4 (0.6)

5.9 (2.1)

6.0 (0.6)

7.4 (1.1)

5.3 (0.7)

7.5 (1.1)

4.9 (0.6)*

7.3 (0.9)

4.1 (0.6)**

6.6 (0.9)

5.1 (0.8)

FEV1

            

Baseline (L)

1.04 (0.07)

1.79 (0.08)**

1.22 (0.10)

1.72 (0.08)*

1.17 (0.06)

1.89 (0.09)**

1.28 (0.07)

1.91 (0.09)**

1.34 (0.07)

2.11 (0.10)**

1.34 (0.06)

2.07 (0.11)**

After 5 years (L)

0.98 (0.08)

1.69 (0.08)**

1.04 (0.13)

1.65 (0.08)**

1.09 (0.05)

1.80 (0.09)**

1.16 (0.07)

1.85 (0.09)**

1.24 (0.07)

2.04 (0.10)**

1.22 (0.06)

2.00 (0.11)**

Annual change (ml/year)

 − 12.7 (8.8)

 − 19.0 (4.5)

 − 36.8 (11.0)

 − 15.3 (4.2)

 − 17.1 (6.7)

 − 18.3 (5.0)

 − 24.2 (7.7)

 − 13.8 (4.3)

 − 20.2 (5.9)

 − 14.8 (4.9)

 − 22.1 (6.1)

 − 12.8 (4.8)*

%FEV1

            

Baseline (%)

50.1 (2.5)

65.4 (2.2)**

53.4 (3.9)

64.1 (2.1)

50.0 (2.7)

68.9 (2.1)**

54.0 (2.8)

68.7 (2.3)**

54.3 (2.0)

74.7 (2.0)**

54.6 (2.0)

73.0 (2.6)**

After 5 years (%)

50.1 (2.7)

65.8 (2.4)**

48.1 (2.7)

65.2 (2.3)**

50.1 (2.9)

69.3 (23)**

52.2 (2.8)

70.4 (2.5)**

53.6 (2.2)

76.6 (5.4)**

53.5 (2.1)

75.0 (2.8)**

Annual change (%/year)

0.001 (0.50)

0.08

 − 1.05 (0.54)

0.22 (0.18)*

0.03 (0.29)

0.08 (0.23)

 − 0.35 (0.35)

0.34 (0.18)

 − 0.16 (0.32)

0.38 (0.19)

 − 0.20 (0.28)

0.40 (0.19)*

Comorbidity

            

Pneumonia n (+ : −)

7:4

19:35

5:3

19:38

13:8

13:31*

15:11

11:28*

20:18

6:21*

19:17

7:22*

Asthma n (+ : −)

7:4

17:37

6:2

18:3*

11:10

13:31

14:12

10:29*

19:19

5:22*

20:16

4:25**

Cancer n (+ : −)

3:8

15:39

1:7

17:40

7:14

11:33

8:18

10:29

11:27

7:20

11:25

7:22

Cardio-vascular dis. n (+ : −)

3:8

14:30

1:7

16:41

8:13

9:35

7:19

10:29

8:30

9:18

9:27

8:21

  1. The data are shown as mean (standard error of the mean) or number ratio. The differences between each pair were analyzed by unpaired t-tests or the chi-squared test
  2. *p < 0.05
  3. **p < 0.01