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Table 4 Univariate and multivariate analysis of clinical parameters on overall survival in patients with SCLC in total population

From: Characteristics and clinical outcomes of patients with nonsmoking small cell lung cancer in Korea

Variables

 

Univariate analysis

 

Multivariate analysis

 
 

No. of cases

HR (95% CI)

P value

HR (95% CI)

P value

Age

1,043

1.041 (1.034–1.049

 < 0.001

1.020 (1.002–1.038)

0.033

Stage, ED

616

2.448 (2.121–2.825)

 < 0.001

1.952 (1.398–2.727)

 < 0.001

Never smoker

154

1.338 (1.119–1.599)

0.001

1.277 (0.676–2.409)

0.451

ECOG PS

     

 2–4 vs. 0–1

144 vs. 655

2.406 (1.987–2.914)

 < 0.001

3.219 (1.860–5.572)

 < 0.001

Gender, male

916

1.150 (0.950–1.392)

0.151

2.247 (1.172–4.305)

0.015

Symptom at diagnosis

82

1.902 (1.466–2.467)

 < 0.001

1.659 (0.969–2.839)

0.065

PCI

70

0.336 (0.261–0.431)

 < 0.001

0.606 (0.403–0.910)

0.016

Active-treatment (chemo and/or TRT)

724

0.408 (0.356–0.468)

 < 0.001

0.291 (0.131–0.644)

0.002

  1. SCLC small cell lung cancer; HR hazard ratio; CI confidence interval; ED extensive disease; ECOG PS Eastern Cooperative Oncology Group Performance status; PCI prophylactic cranial irradiation; TRT thoracic radiotherapy