Table 5 Univariate and multivariate analysis of clinical parameters on overall survival in patients with LD and ED-SCLC

Age

1,043

1.049 (0.133–0.064)

 < 0.001

1.007 (0.983–1.031)

0.595

1.040 (1.030–1.050)

 < 0.001

1.036 (1.009–1.064)

0.008

Gender (male)

916

1.215 (0.873–1.691)

0.249

1.863 (0.844–4.111)

0.124

0.968 (0.763–1.228)

0.786

2.496 (0.650–9.585)

0.183

Never smoking

154

1.260 (0.899–1.766)

0.180

2.410 (1.012–5.697)

0.047

1.348 (1.086–1.675)

0.007

1.392 (0.428–4.530)

0.582

ECOG PS(≥ 2)

144

2.306 (1.612–3.300)

 < 0.001

2.408 (0.984–5.894)

0.054

2.623 (2.073–3.318)

 < 0.001

3.244 (1.543–6.820)

0.002

Symptom at diagnosis

82

1.914 (1.302–2.812)

0.001

2.082 (1.023–4.237)

0.043

1.357 (0.939–1.959)

0.104

1.215 (0.512–2.883)

0.659

PCI

70

0.463 (0.296–0.726)

0.001

0.527 (0.320–0.868)

0.012

0.798 (0.427–1.489)

0.478

1.131 (0.517–2.477)

0.758

Chemo + TRT

136

0.467 (0.359–0.608)

 < 0.001

0.472 (0.295–0.755)

0.002

0.356 (0.196–0.648)

0.001

0.044 (0.009–0.220)

 < 0.001

Chemo only

588

0.462 (0.389–0.548)

 < 0.001

0.069 (0.018–0.273)

 < 0.001

Pleural effusion

173

2.062 (1.356–3.136)

 < 0.001

1.831 (1.005–3.336)

0.048

Pleural nodules

74

1.334 (1.029–1.731)

0.030

1.167 (0.460–2.959)

0.745

Bone meta

260

1.373 (1.166–1.616)

 < 0.001

1.544 (0.993–2.402)

0.054

Brain

184

0.897 (0.753–1.069)

0.223

1.675 (1.067–2.630)

0.025

Liver meta

219

1.728 (1.457–2.049)

 < 0.001

2.251 (1.368–3.705)

0.001

Adrenal meta

104

1.128 (0.908–1.401)

0.276

1.648 (0.858–3.168)

0.134