Table 4 Association of STAS with genetic mutations
Data |  | All patients (n = 3075) n (%) | STAS | p | |
|---|---|---|---|---|---|
Present (n = 617) | Absent (n = 2458) | ||||
n (%) | n (%) | ||||
Gene mutation types | |||||
EGFR mutant | − | 1278 (44.79) | 320 (25.04) | 958 (74.96) |  < 0.001 |
|  |  +  | 1575 (55.21) | 284 (18.03) | 1291 (81.97) |  |
KRAS mutant | − | 2728 (96.33) | 541 (19.83) | 2187 (80.19) |  < 0.001 |
|  |  +  | 104 (3.67) | 59 (56.73) | 45 (43.27) |  |
BRAF mutant | − | 2764 (99.57) | 543 (19.65) | 2221 (80.35) | 0.069 |
|  |  +  | 12 (0.43) | 5 (41.67) | 7 (58.33) |  |
PIK3CA mutant | − | 2761 (99.46) | 546 (19.78) | 2215 (80.22) | 0.749 |
|  |  +  | 15 (0.54) | 2 (13.33) | 13 (86.67) |  |
HER2 mutant | − | 2727 (98.31) | 538 (19.73) | 2189 (80.27) | 0.853 |
|  |  +  | 47 (1.69) | 10 (21.28) | 37 (78.72) |  |
ALK genetic isolation | − | 2730 (96.36) | 555 (20.33) | 2175 (79.67) |  < 0.001 |
|  |  +  | 103 (3.64) | 46 (44.66) | 57 (55.34) |  |
ROS1 genetic isolation | − | 2820 (99.44) | 588 (20.85) | 2232 (79.15) |  < 0.001 |
|  |  +  | 16 (0.56) | 14 (87.50) | 2 (12.50) |  |
RET genetic isolation | − | 2747 (98.96) | 540 (19.66) | 2207 (80.34) | 0.489 |
|  |  +  | 29 (1.04) | 7 (24.14) | 22 (75.86) |  |