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Table 5 Factors associated with respiratory virus co-infection in children with MP pneumonia

From: Clinical significance of respiratory virus coinfection in children with Mycoplasma pneumoniae pneumonia

Variables

OR

P value

aOR*

P value

aOR**

P value

Age at diagnosis of pneumonia, years

0.881 (0.800–0.970)

0.010

0.879 (0.798–0.969)

0.009

0.898 (0.809–0.997)

0.045

Duration of fever during illness ≥ 6 days

2.105 (1.074–4.123)

0.030

2.394 (1.172–4.892)

0.017

3.329 (1.540–7.196)

0.002

Total duration of hospitalization, days

1.083 (1.005–1.167)

0.037

1.070 (0.992–1.154)

0.080

1.060 (0.979–1.147)

0.152

Severity of pneumonia based on chest radiography findings at admission

 Mild

Ref.

 

Ref.

 

Ref.

 

 Moderate

2.050 (0.609-6.900)

0.246

2.746 (0.787–9.578)

0.113

2.485 (0.589–10.490)

0.215

 Severe

3.094 (0.820-11.672)

0.096

4.602 (1.154–18.353)

0.031

4.184 (0.875–20.011)

0.073

WBC, x 103/µL

1.085 (1.008–1.168)

0.030

1.065 (0.988–1.148)

0.102

1.053 (0.974–1.139)

0.193

AST ≥ 44 IU/L

3.300 (1.577–6.906)

0.002

3.491 (1.616–7.543)

0.001

5.202 (2.211–12.238)

< 0.001

ALT ≥ 33 IU/L

2.749 (1.290–5.856)

0.009

3.325 (1.478–7.477)

0.004

4.756 (1.903–11.887)

0.001

LDH ≥ 805.3 IU/L

6.250 (2.878–13.574)

< 0.001

5.704 (2.602–12.504)

< 0.001

6.555 (2.772–15.503)

< 0.001

CRP, mg/dL

0.939 (0.866–1.019)

0.132

0.972 (0.898–1.051)

0.471

0.960 (0.885–1.042)

0.333

MP-specific IgM titer at the time of admission, index

1.129 (1.014–1.257)

0.026

1.109 (0.993–1.239)

0.065

1.121 (0.995–1.263)

0.061

Response to treatment

 Good response

Ref.

 

Ref.

 

Ref.

 

 Slow response

2.187 (1.041–4.599)

0.039

2.187 (1.041–4.599)

0.039

2.197 (0.931–5.185)

0.072

 No/poor response

4.354 (1.374–13.800)

0.012

4.354 (1.374–13.800)

0.012

4.410 (1.273–15.277)

0.019

  1. Bold values denote statistical significance
  2. aOR adjusted odds ratio, AST aspartate aminotransferase, ALT alanine aminotransferase, CRP C-reactive protein, IgM immunoglobulin M, LDH lactate dehydrogenase, MP Mycoplasma pneumoniae, NA not applicable, PCR polymerase chain reaction, Ref. reference
  3. *Adjusted by age and sex
  4. **Adjusted by age, sex, and bacterial coinfection identified using Pneumobacter PCR or respiratory culture from sputum samples
  5. The variables were dichotomized based on the mean values