Table1 Demographics, WHO-Fc, NT-proBNP hemodynamics and cardiopulmonary exercise testing in IPAH, CTEPH and Control subjects

Age, years

34.75 ± 13.81

40.01 ± 15.20

59.33 ± 12.64#

Gender, male/female

26/18

50/114

60/75#

BMI, kg/m²

23.10 ± 2.67

22.69 ± 3.50

23.35 ± 3.13

WHO-Fc, I-II/III-IV

N

66/98

41/94

NT-proBNP, pg/ml

N

994.89 ± 1094.07

1261.95 ± 1353.18

Hemodynamics

mRAP, mmHg

N

5.89 ± 4.34

4.31 ± 4.11#

mPAP, mmHg

N

56.02 ± 13.35

45.93 ± 13.33#

PAWP, mmHg

N

7.21 ± 3.69

7.24 ± 3.91

CO, L/min

N

4.46 ± 1.57

4.67 ± 1.40#

CI, L/min/m²

N

2.63 ± 0.83

2.86 ± 0.69#

PVR, IU

N

12.96 ± 5.64

8.79 ± 4.17#

Cardiopulmonary exercise testing

PetCO₂ at rest, mmHg

33.85 ± 4.07

26.78 ± 4.27

24.70 ± 3.97#

PetCO₂ at unloaded, mmHg

37.33 ± 3.93

27.01 ± 5.36

24.42 ± 5.30#

PetCO₂ at AT, mmHg

42.77 ± 5.06

26.94 ± 6.11

24.36 ± 5.81#

PetCO₂ at peak, mmHg

39.58 ± 5.90

24.69 ± 6.49

22.49 ± 6.61#

peak VO₂, ml/min

2148.17 (1496.67, 2527.58)

714.50 (567.50, 928.08)

727.33 (588.00, 853.00)

VO₂/kg at peak, mL/min/kg

33.70 (29.35, 36.70)

12.30 (9.81, 15.45)

11.81 (10.32, 13.72)