Table 2 CPET parameters, NT-pro BNP and Hemodynamics in normal subjects and IPAH patients classified according to peakVO2%pred
From: Variation of PetCO2 during incremental exercise and severity of IPAH and CTEPH
IPAH | Control (n = 44) | Mild (n = 9) | Moderate (n = 36) | Severe (n = 68) | Very severe (n = 51) |
|---|---|---|---|---|---|
PetO2 at Unloaded, mmHg | 108.82 ± 5.09 | 115.20 ± 3.53* | 115.60 ± 5.24* | 122.09 ± 5.64*#ф | 125.59 ± 4.88*#ф§ |
PetCO2 at Unloaded, mmHg | 37.33 ± 3.93 | 31.06 ± 4.66* | 31.29 ± 4.36* | 26.01 ± 5.16*#ф | 23.33 ± 4.60*#ф§ |
PetO2 at AT, mmHg | 103.08 ± 6.22 | 114.58 ± 5.32* | 114.88 ± 5.90* | 121.90 ± 5.88*ф | 124.11 ± 17.41*ф |
PetCO2 at AT, mmHg | 42.77 ± 5.06 | 31.67 ± 5.79* | 32.29 ± 4.90* | 26.09 ± 5.33*#ф | 22.61 ± 4.08*#ф§ |
Peak load, W/min | 178.08 ± 55.78 | 85.18 ± 20.05* | 85.92 ± 25.06* | 62.29 ± 24.61*ф | 52.08 ± 19.13*ф |
Peak load, %pred | 105.93 ± 22.61 | 100.06 ± 10.54 | 72.69 ± 13.49*# | 49.08 ± 13.58*#ф | 34.91 ± 12.57*#ф§ |
Peak VO2, L/min | 2066.22 ± 613.89 | 987.48 ± 165.97* | 985.88 ± 193.87* | 749.84 ± 203.76*ф | 565.85 ± 139.89*#ф§ |
Peak VO2, %pred | 92.25 ± 9.75 | 72.24 ± 5.00* | 57.34 ± 4.67*# | 41.22 ± 4.59*#ф | 27.83 ± 3.78*#ф§ |
Peak PetO2, mmHg | 116.33 ± 5.11 | 121.35 ± 7.23 | 122.41 ± 4.68* | 127.88 ± 4.93*#ф | 131.34 ± 5.22*#ф§ |
Peak PetCO2, mmHg | 39.58 ± 5.90 | 29.68 ± 7.51* | 30.12 ± 5.44* | 23.48 ± 5.43*#ф | 20.36 ± 4.90*#ф§ |
NT-proBNP, pg/ml | – | 474.44 ± 627.95 | 255.02 ± 323.14 | 1076.07 ± 1159.07 | 1502.36 ± 1120.00 |
mPAP, mmHg | – | 45.50 ± 16.61 | 50.35 ± 13.43 | 57.44 ± 11.05 | 59.60 ± 11.57 |
CO, L/min | – | 5.84 ± 2.05 | 5.49 ± 1.47 | 4.30 ± 1.58 | 3.77 ± 1.00 |
CI, L/min/m2 | – | 3.70 ± 1.18 | 3.19 ± 0.72 | 2.49 ± 0.77 | 2.30 ± 0.59 |
PVR, IU | – | 8.48 ± 3.88 | 8.92 ± 3.94 | 13.55 ± 4.91 | 15.37 ± 6.15 |