Table 3 CPET parameters, NT-pro BNP and Hemodynamics in normal subjects and CTEPH patients classified according to peakVO2%pred
From: Variation of PetCO2 during incremental exercise and severity of IPAH and CTEPH
CTEPH | Control (n = 44) | Mild (n = 30) | Moderate (n = 47) | Severe (n = 36) | Very severe (n = 22) |
|---|---|---|---|---|---|
PetO2 at Unloaded, mmHg | 108.82 ± 5.09 | 119.39 ± 5.84* | 123.36 ± 5.67* | 125.28 ± 5.28*# | 128.19 ± 6.28*#ф |
PetCO2 at Unloaded, mmHg | 37.33 ± 3.93 | 27.04 ± 5.20* | 25.17 ± 4.48* | 23.04 ± 5.06*# | 20.53 ± 5.01*#ф |
PetO2 at AT, mmHg | 103.08 ± 6.22 | 117.76 ± 6.94* | 123.92 ± 6.02*# | 126.26 ± 5.22*# | 129.26 ± 5.98*#ф |
PetCO2 at AT, mmHg | 42.77 ± 5.06 | 28.34 ± 6.15* | 24.90 ± 4.81* | 22.41 ± 5.08*# | 20.28 ± 5.29*#ф |
Peak load,W/min | 178.08 ± 55.78 | 69.70 ± 30.41* | 66.16 ± 22.85* | 59.19 ± 22.05* | 45.56 ± 26.88* |
Peak load, %pred | 105.93 ± 22.61 | 81.33 ± 25.22* | 72.81 ± 17.50* | 52.25 ± 14.25*#ф | 30.36 ± 15.48*#ф§ |
Peak VO2, L/min | 2066.22 ± 613.89 | 921.24 ± 236.47* | 786.22 ± 182.26* | 681.24 ± 165.14*# | 549.26 ± 161.66*# |
Peak VO2, %pred | 92.25 ± 9.75 | 73.03 ± 9.03* | 56.43 ± 4.63*# | 42.31 ± 4.14*#ф | 29.59 ± 3.05*#ф§ |
Peak PetO2, mmHg | 116.33 ± 5.11 | 122.73 ± 7.16* | 126.28 ± 14.74* | 130.06 ± 6.40*# | 132.38 ± 6.87*# |
Peak PetCO2, mmHg | 39.58 ± 5.90 | 26.99 ± 6.53* | 22.84 ± 5.61*# | 20.71 ± 5.94*# | 18.24 ± 5.53*#ф |
NT-proBNP, pg/ml | – | 484.25 ± 588.64 | 1094.14 ± 1383.23 | 1546.67 ± 2131.68 | 2113.27 ± 1620.82 |
mPAP, mmHg | – | 40.03 ± 11.89 | 45.54 ± 13.15 | 48.00 ± 14.44 | 51.14 ± 11.21 |
CO, L/min | – | 4.88 ± 1.92 | 4.91 ± 1.14 | 4.52 ± 1.13 | 4.11 ± 1.40 |
CI, L/min/m2 | – | 3.23 ± 0.79 | 2.95 ± 0.67 | 2.68 ± 0.56 | 2.55 ± 0.64 |
PVR, IU | – | 6.55 ± 3.47 | 8.19 ± 3.71 | 10.07 ± 4.44 | 10.76 ± 4.13 |