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Fig. 6 | BMC Pulmonary Medicine

Fig. 6

From: C1QTNF6 regulated by miR‐29a-3p promotes proliferation and migration in stage I lung adenocarcinoma

Fig. 6

RNA-Seq of C1QTNF6 between A549 knockdown and control cells. A Heat map of the differentially expressed genes in the A549 knockdown cells. The red color indicates differentially expressed genes with high expression, while the green color indicates low expression. B Gene Ontology analysis of the differentially expressed genes. C KEGG pathway analysis on the differentially expressed genes. D Heat map of DEGs enriched in the cytokine-cytokine receptor interaction pathway (map04060). E mRNA expressions of cytokine-cytokine receptor interaction genes after upregulation or downregulation of C1QTNF6 expression were detected by RT-qPCR. OE, overexpression; miR‐29a-3p, miR‐29a-3p mimics; NC, negative control; 3'UTR, 3'‐untranslated region. n = 3. (Data were presented as the mean ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)

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