Fig. 6

Linc00511 promotes the proliferation, migration and invasion of lung adenocarcinoma cells by regulating COL1A1 expression. A Measurement of the COL1A1 overexpression efficiency by RT–qPCR in A549 and PC9 cells. B–F Cell proliferation (B), colony formation (C), apoptosis (D), migration (E) and invasion (F) were evaluated in A549 and PC9 cells transfected with si-nc, si-Linc00511, si-Linc00511 + vector or si-Linc00511 + COL1A1. G The PI3K, phosphorylated PI3K (p-PI3K), AKT, and phosphorylated AKT (p-AKT) levels were determined by western blot analysis in LUAD cells with Linc00511 silencing or forced COL1A1 expression. * P < 0.05, ** P < 0.01, ***P < 0.001 versus the si-nc group; ^# P < 0.05, ^## P < 0.01, ^###P < 0.001 versus the si-linc00511 + vector group