Mixed venous oxygen tension is a crucial prognostic factor in pulmonary hypertension: a retrospective cohort study

Table 2 Characteristics of patients with CTEPH stratified by PvO₂ of 35 mmHg

Variable	PvO₂		P
Variable	≥ 35 mmHg	< 35 mmHg	P
N	84	184
Age (years)	55.6 ± 14.7	58.2 ± 12.1	0.297
Sex (F/M)	57/27	138/46	0.223
RAP (mmHg)	3.3 ± 2.6	6.3 ± 4.1	< 0.001
mPAP (mmHg)	37.3 ± 8.8	47.1 ± 10.3	< 0.001
CI (L/min/m²)	3.0 ± 0.6	2.4 ± 0.6	< 0.001
PVR (W.U)	6.6 ± 2.8	10.9 ± 4.2	< 0.001
PaO₂ (mmHg)	66.2 ± 9.5	55.0 ± 8.0	< 0.001
PvO₂ (mmHg)	37.6 ± 2.4	31.1 ± 2.7	< 0.001
SvO₂ (mmHg)	70.1 ± 4.0	58.9 ± 6.0	< 0.001
A-aDO₂ (mmHg)	36.0 ± 11.0	49.2 ± 8.7	< 0.001
BNP (pg/mL)	69.2 ± 109.3	285.0 ± 329.2	< 0.001
6MWD (m)	409.6 ± 99.9	340.3 ± 92.2	< 0.001
FVC, %pred. (%)	97.9 ± 20.4	93.1 ± 18.0	0.031
DLCO, %pred. (%)	79.1 ± 18.8	73.3 ± 21.1	0.021
WHO functional class I, II, III, IV	4/45/33/2	1/49/121/13	< 0.001
PEA/BPA, n (%)	49 (58.3%)	128 (69.6%)	0.005*
PH medication, n (%)	20 (23.8%)	46 (25.0%)
Supportive, n (%)	15 (17.9%)	10 (5.4%)

Statistically significant, P < 0.05, are shown in bold
Data are presented as mean ± standard deviation or numbers
A-aDO₂ alveolar-arterial oxygen gradient, BNP brain natriuretic peptide, BPA balloon pulmonary angioplasty, CI cardiac index, CTEPH chronic thromboembolic pulmonary hypertension, DLCO, %pred. percent predicted carbon monoxide diffusing capacity, FVC, %pred. percent predicted forced vital capacity, mPAP mean pulmonary arterial pressure, PaO₂ arterial oxygen tension, PEA pulmonary endarterectomy, PH pulmonary hypertension, PvO₂ mixed venous oxygen tension, PVR pulmonary vascular resistance, RAP right arterial pressure, SvO₂ mixed venous oxygen saturation, WHO World Health Organization, W.U Wood units, 6MWD 6-min walk distance
*There was a significant difference in treatment between the two groups

ISSN: 1471-2466