The performance of detecting Mycobacterium tuberculosis complex in lung biopsy tissue by metagenomic next-generation sequencing

Table 1 Clinical information of the enrolled patients with TB

Patient	Gender	Age	Smoking	Disease history	CT diagnosis*	Sample	Sputum stain*	Xpert*
1	M	48	N	N	U/U, M	BALF	Neg × 3	L
2	M	80	1200	Pulmonary emphysema	U/U, M	BALF	Neg × 3	L
3	M	35	N	Uremia, Post renal transplant	U, L/U, M, L	BALF	Neg × 2	L
4	M	29	N	N	U/ (−)	BALF	Neg × 2	M
5	M	62	N	T2DM	U/U	BALF	Neg × 4	L
6	F	19	N	N	L/ (−)	BALF	Neg × 3	L
7	M	68	N	N	U/U, M	BALF	Neg × 3	Neg
8	M	68	1000	Hypertension, LA, Syphilis	L/ (−)	BALF	1 +	H
9	F	77	N	Hypertension	U, L/U, M, L	BALF	Neg × 3	L
10	F	56	N	Hepatitis B	(−)/U, M	BALF	Neg × 2	L
11	F	78	N	COPD, Bronchiectasis, CI	L/M, L	BALF	Neg × 3	M
12	F	78	N	N	L/ (−)	BALF	Neg × 2	L
13	F	45	N	Heart failure, PAH	U/U, M, L	BALF	Neg × 3	M
14	F	30	N	AML, UCBCT	U, L/U, M, L	BALF	Neg × 3	L
15	M	57	N	LUSC of left lung	U/ (−)	BALF	Neg × 2	L
16	M	57	800	N	U, L/U, M, L	BALF	Neg × 2	M
17	M	38	N	N	(−)/U, M	BALF	Neg × 2	L
18	F	24	N	N	U, L/ (−)	BALF	Neg × 3	H
19	M	62	N	N	(−)/U, M	BALF	Neg × 3	H
20	M	35	N	N	(−)/U, M, L	BALF	Neg × 2	L
21	M	81	800	COPD, CHD	(−)/M, L	BALF	Neg × 3	L
22	F	78	N	N	U/ (−)	R-EBUS-TBLB	Neg × 2	H
23	M	38	N	N	U, L/ (−)	R-EBUS-TBLB	Neg × 2	L
24	M	80	2400	N	U/U	R-EBUS-TBLB	Neg × 2	M
25	F	79	N	N	(−)/M, L	R-EBUS-TBLB	Neg × 2	L
26	M	56	N	CHD	U/ (−)	R-EBUS-TBLB	Neg × 3	Neg
27	M	21	N	N	(−)/L	R-EBUS-TBLB	Neg × 2	M
28	F	65	N	N	U, L/U, M, L	CPLP	Neg × 2	L
29	M	32	30	N	(−)/U	CPLP	Neg × 2	M
30	M	25	100	N	U/ (−)	CPLP	Neg × 2	L
31	M	84	600	T2DM, Hypertension	(−)/U	CPLP	Neg × 2	L
32	M	56	N	Esophagus cancer	U/ (−)	CPLP	Neg × 2	L
33	M	55	600	T2DM	(−)/U	CPLP	Neg × 2	H
34	M	41	N	Epilepsy	U, L/U, M, L	CPLP	Neg × 3	L
35	F	16	N	Nephrotic syndrome	(−)/L	CPLP	Neg × 2	L
36	F	67	N	N	L/L	CPLP	Neg × 2	L

*In the column of Smoking and Disease history, the numbers in the table indicate smoking index. The average root number per day multiplied by smoking years of smoking, that is, smoking index. N refers to non-smoking. *In the column of CT diagnosis shows the location of the TB lesion in each patient. The left side of the ‘/’ refers to the left lung and the right side refers to the right lung. U, M, L refer to the upper, middle and lower lobi of lungs, respectively, and ‘−’ refers to lesion-free lungs. *In the column in Sputum stain shows the result and time of sputum stain test. ‘−’ refers to negative. *In the column Xpert, L, M and H respectively refers to low abundance, medium abundance and high abundant. T2DM = Type 2 diabetes, LA = lung adenocarcinoma, COPD = chronic obstructive pulmonary disease, CI = cardiac insufficiency, PAH = pulmonary arterial hypertension, AML = acute myelogenous leukemia, UCBCT = umbilical cord blood stem cell transplantation, LUSC = lung squamous cell carcinoma, CHD = coronary heart disease, R-EBUS-TBLB = radial endobronchial ultrasound transbronchial lung biopsy, CPLP = CT-guide percutaneous lung puncture biopsy

ISSN: 1471-2466