Fig. 9

Metabonomics analysis of Ttc39c and its metabolites in LUAD. KEGG pathway enrichment (Top 20 metabolic pathways with the highest significance). The bigger the bubble, the bigger the influence factor; The color of bubbles indicates the P value of enrichment analysis. The darker the color, the smaller the P value, and the more significant the enrichment degree. Rich factor represents the proportion of the number of differential metabolites in this pathway to the number of metabolites annotated in this pathway. (B) Differential abundance scores of all differential metabolic pathways (classification and attribution according to Pathway_Hierarchy). Y-axis represents the name of the differential pathway, and X-axis coordinates represent the differential abundance score. DA score is the total change of all metabolites in metabolic pathway. A score of 1 indicates that the expression trend of all identified metabolites in this pathway is up-regulated, and − 1 indicates that the expression trend of all identified metabolites in this pathway is down-regulated. The length of the line segment indicates the absolute value of DA score, the dot size at the end of the line segment indicates the number of metabolites in the pathway, and the larger the dot, the more metabolites. It is proportional to the depth of dot color and DA score value. The darker the red color is, the more the expression of this channel tends to be up-regulated. The darker the blue color is, the more it tends to be down-regulated