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Table 5 Univariate and multivariate analysis of DFS and clinicopathological variables

From: Relationship between the expression of ARHGAP25 and RhoA in non-small cell lung cancer and vasculogenic mimicry

  

Univariable Analysis

Multivariable Analysis

Variables

Number

HR (95% CI)

P

HR (95% CI)

P

ARHGAP25

 

0.405(0.269–0.612)

 < 0.001

0.431(0.280–0.663)

 < 0.001

 Negative

67

    

 Positive

63

    

RHOA

 

2.751(1.772–4.271)

 < 0.001

2.031(1.263–3.266)

0.003

 Negative

49

    

 Positive

81

    

VM

 

2.722(1.814–4.084)

 < 0.001

1.958(1.263–3.036)

0.003

 Negative

82

    

 Positive

48

    

Tumor size (cm)

 

2.078(1.361–3.172)

0.001

1.965(1.213–3.181)

0.006

  ≤ 3

50

    

  > 3

80

    

Age (years)

 

0.923(0.618–1.378)

0.695

  

  < 60

57

    

  ≥ 60

73

    

Gender

 

0.878(0.557–1.385)

0.575

  

 Female

34

    

 Male

96

    

Smoking

 

1.231(0.828–1.831)

0.305

  

 No

68

    

 Yes

62

    

Gross type

 

0.834(0.551–1.262)

0.390

  

 Central

83

    

 Peripheral

47

    

Histologic type

 

1.293(0.865–1.933)

0.211

  

 LUSC

75

    

 LUAD

55

    

Grade

 

1.344(0.960–1.882)

0.085

  

 Well

16

    

 Moderate

81

    

 Poor

33

    

LNM

 

7.361(4.464–12.137)

 < 0.001

3.805(2.024–7.153)

 < 0.001

 No

58

    

 Yes

72

    

TNM stage

 

3.172(2.411–4.172)

 < 0.001

2.411(1.712–3.394)

 < 0.001

 I

40

    

 II

33

    

 III

57

    
  1. NSCLC, non-small cell lung cancer; ARHGAP25, Rho GTPase-activating protein 25; RhoA, Ras homolog family member A; VM, vasculogenic mimicry; TNM, tumor-node-metastasis; LNM, lymph node metastasis; LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma