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Table 4 Univariate and Multivariate Analyses of Clinical Parameters on OS

From: Impact of opioid analgesics on the efficacy of immune checkpoint inhibitors in a lung cancer population

Factor

Univariate Analysis

Multivariate Analysis

HR (95% CI)

P Value

HR (95% CI)

P Value

Age, year (< 65 vs. ≥ 65)

1.542 (0.910, 2.612)

0.107

——

——

Gender (female vs. male)

0.799 (0.422 1.515)

0.492

——

——

Smoking (never vs. smoker)

0.655 (0.387, 1.108)

0.058

0.814(0.477, 1.387)

0.449

Family History (yes vs no)

1.150 (0.563, 2.348)

0.701

——

——

ECOG PS (< 2 vs ≥ 2)

1.969 (1.164, 3.331)

0.011

2.364(1.392, 4.017)

0.001

Histology (NSCLC vs SCLC)

1.054 (0.742, 1.497)

0.769

——

——

Neoplasm staging(III vs IV)

3.436 (1.072, 11.006)

0.038

2.834(0.873, 9.198)

0.083

No. of treatment line (1 vs ≥ 2)

1.637 (0.893, 3.000)

0.111

——

——

Recurrence after operation(yes vs no)

0.534 (0.213, 1.340)

0.182

——

——

Treatment regimen (combination vs. monotherapy)

0.928 (0.567, 1.517)

0.766

——

——

OA treated (yes vs no)

3.582 (2.103, 6.102)

 < 0.001

3.618(2.030, 6.240)

 < 0.001